The distribution of superficial zone protein (SZP)/lubricin/PRG4 and boundary mode frictional properties of the bovine diarthrodial joint.
The distribution of superficial zone protein (SZP)/lubricin/PRG4 and boundary mode frictional properties of the bovine diarthrodial joint.
复制标题
DOI：
10.1016/j.jbiomech.2015.05.032
复制
发表时间：
2015-09-18
影响因子：
2.4
通讯作者：
Reddi AH
中科院分区：
文献类型：
--
作者：
Peng G;McNary SM;Athanasiou KA;Reddi AH
膝关节是一个非常有效的关节面系统;关节软骨表面提供几乎无摩擦的性能，磨损最小。软骨表面的低摩擦特性部分是由于边界润滑剂，表面区蛋白（SZP）;也称为润滑素或蛋白聚糖4（PRG 4）。在以前的工作中，SZP定位和软骨摩擦检查整个股骨髁。文献中的研究还单独研究了构成人类膝关节和四足动物后膝关节的其他组织，如半月板或髌骨。然而，由于所采用的可变测试条件，个体研究之间的比较有限。摩擦力是一种系统属性，取决于相对的关节面、牵引速度和载荷。因此，需要使用常见的测试配置对膝关节/后膝关节组织的摩擦性能和SZP定位进行交叉比较。本研究的目的是确定组成牛后膝关节三个隔室的组织的摩擦系数和SZP定位：髌骨、髌股沟、股骨髁、半月板、胫骨平台和前交叉韧带。髌股间室组织的边界模式摩擦系数大于外侧和内侧胫股间室。SZP免疫定位遵循这一趋势，与股骨髁和胫骨平台相比，髌骨和髌股沟的染色深度和强度降低。这些结果说明了SZP在减少膝关节/后膝关节的组织和隔室中的摩擦方面的重要作用。
The diarthrodial, knee joint is a remarkably efficient bearing system; articulating cartilage surfaces provide nearly frictionless performance with minimal wear. The low friction properties of the cartilage surfaces are due in part to the boundary lubricant, superficial zone protein (SZP); also known as lubricin or proteoglycan 4 (PRG4). In previous work, SZP localization and cartilage friction were examined across the femoral condyles. Studies in the literature have also individually investigated the other tissues that comprise the human knee and four-legged animal stifle joint, such as the meniscus or patella. However, comparisons between individual studies are limited due to the variable testing conditions employed. Friction is a system property that is dependent on the opposing articulating surface, entraining speed, and loading. A cross-comparison of the frictional properties and SZP localization across the knee/stifle joint tissues utilizing a common testing configuration is therefore needed. The objective of this investigation was to determine the friction coefficient and SZP localization of the tissues comprising the three compartments of the bovine stifle joint: patella, patellofemoral groove, femoral condyles, meniscus, tibial plateau, and anterior cruciate ligament. The boundary mode coefficient of friction was greater in tissues of the patellofemoral compartment than the lateral and medial tibiofemoral compartments. SZP immunolocalization followed this trend with reduced depth of staining and intensity in the patella and patellofemoral groove compared to the femoral condyles and tibial plateau. These results illustrate the important role of SZP in reducing friction in the tissues and compartments of the knee/stifle joint.