CTCF: an architectural protein bridging genome topology and function.
CTCF: an architectural protein bridging genome topology and function.
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DOI：
10.1038/nrg3663
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Corces VG
中科院分区：
文献类型：
--
作者：
Ong CT;Corces VG
真核生物基因组在三维核空间中以特定的方式组织，这既是其功能的原因也是其结果。这种组织部分是由一类特殊的建筑蛋白建立的，其中CTCF是最具特征的。尽管CTCF被赋予了各种经常相互矛盾的作用，但新的研究结果有助于建立一个统一的模型来解释这种蛋白质的许多功能。CTCF在染色体拓扑相关结构域之间建立边界，在这些结构域内，CTCF促进转录调控序列之间的相互作用。因此，CTCF将基因组的结构与其功能联系起来。
The eukaryotic genome is organized in the three-dimensional nuclear space in a specific manner that is both a cause and a consequence of its function. This organization is in part established by a special class of architectural proteins of which CTCF is the best characterized. Although CTCF has been assigned a variety of often contradictory roles, new results help draw a unifying model to explain the many functions of this protein. CTCF creates boundaries between topologically associating domains in chromosomes and, within these domains, CTCF facilitates interactions between transcription regulatory sequences. Thus, CTCF links the architecture of the genome to its function.