Primary tumors of the spine: a review of clinical features in 438 patients
Primary tumors of the spine: a review of clinical features in 438 patients
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DOI：
10.1007/s11060-014-1650-8
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发表时间：
2015-02-01
影响因子：
3.9
通讯作者：
Liu, Zhongjun
中科院分区：
文献类型：
--
作者：
Dang, Lei;Liu, Xiaoguang;Liu, Zhongjun
原发性脊柱肿瘤是罕见的。因此，由于缺乏大队列研究，目前对该主题的了解有限。本研究旨在分享我们从大量患者中收集的原发性脊柱肿瘤临床资料。回顾性总结438例患者的临床表现，并进行统计学分析。在脊柱中，良性肿瘤比恶性肿瘤多见。最常见的肿瘤是巨细胞瘤。肿瘤主要发生在18岁至59岁之间，40岁后恶性肿瘤的风险显着增加。主要症状为局部疼痛和神经系统症状，常出现神经功能缺损和病理性骨折。疼痛是由肿瘤扩大、病理性骨折和神经卡压引起的。神经功能缺损的发生与患者的年龄和受累区域显著相关。骨巨细胞瘤与神经系统骨折的发生率最高，具有显著性意义。症状持续时间平均为6个月。最受影响的区域是颈椎，其次是胸椎和腰椎。骶骨和尾骨的肿瘤更可能是恶性的。恶性肿瘤多节段受累的发生率明显高于良性肿瘤。这项研究有助于提高我们对这种罕见临床实体的理解。
Primary spinal tumors are rare. Current knowledge on this subject is therefore limited due to the lack of study with large cohort. This study is prompted to share our data on clinical profiles of primary spinal tumors collected from a large series of patients. Clinical manifestations of 438 consecutive patients were summarized retrospectively with statistical analysis. In the spine, benign tumor is more common than malignant. The most prevalent tumor is giant cell tumor. Tumors predominately occur between the age of 18 and 59 and the risk of malignancy increases significantly after 40. Main symptoms include local pain and neurological symptoms with frequent occurrence of neurological deficits and pathological fracture. Pain is caused by tumor expansion, pathological fracture and nerve entrapment. Occurrence of neurological deficits is significantly related to patent's age and the region of involvement. Giant cell tumor is associated with the highest incidence of neurological fracture with significance. Duration of symptom is 6 months on average. The most affected region is the cervical spine, followed by the thoracic and the lumbar spine. Tumors at the sacrum and coccyx are more likely to be malignant. Malignant tumors have significantly higher incidence of involvement at multiple levels than benign tumors. This study contributes by improving our understanding of this rare clinical entity.