High-gain, low-noise amplification in olfactory transduction
High-gain, low-noise amplification in olfactory transduction
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DOI：
10.1016/s0006-3495(97)78143-8
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发表时间：
1997-08-01
影响因子：
3.4
通讯作者：
Kleene, SJ
中科院分区：
文献类型：
--
作者：
Kleene, SJ
感觉系统需要使用高增益、低噪声放大来将微弱的刺激转换为可检测的信号。这里表明，脊椎动物嗅觉转导的一对受体电流构成了这样的方案。主要受体电流是 Na+ 和 Ca2+ 通过嗅觉纤毛中的 cAMP 门控通道流入，外部二价阳离子改善该电流的信噪比特性，降低平均电流和电流方差，当 Ca2+ 进入纤毛时，它门控 Cl- 通道，激活次级去极化受体电流，该电流放大初级电流，但引入很少的额外噪声，两个电流加上粘液中二价阳离子的系统产生大的接收器电流且噪声非常低。
It is desirable that sensory systems use high-gain, low-noise amplification to convert weak stimuli into detectable signals. Here it is shown that a pair of receptor currents underlying vertebrate olfactory transduction constitutes such a scheme. The primary receptor current is an influx of Na+ and Ca2+ through cAMP-gated channels in the olfactory cilia, External divalent cations improve the signal-to-noise properties of this current, reducing the mean current and the current variance, As Ca2+ enters the cilium, it gates Cl- channels, activating a secondary depolarizing receptor current, This current amplifies the primary current, but introduces little additional noise, The system of two currents plus divalent cations in the mucus produces a large receptor current with very low noise.