Experimental study on the regeneration of peripheral nerve gaps through a polyglycolic acid-collagen (PGA-collagen) tube
Experimental study on the regeneration of peripheral nerve gaps through a polyglycolic acid-collagen (PGA-collagen) tube
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DOI：
10.1016/j.brainres.2004.08.040
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发表时间：
2004-11-19
期刊：
影响因子：
2.9
通讯作者：
Shimizu, Y
中科院分区：
文献类型：
--
作者：
Nakamura, T;Inada, Y;Shimizu, Y
我们开发了一种填充有胶原海绵的生物可吸收聚乙醇酸（PGA）管（PGA-胶原蛋白管）作为神经连接引导器，并比较了其与自体移植物在跨间隙神经再生方面的有效性。 PGA 胶原蛋白管被植入 24 只比格犬体内，其左腓神经间隙为 15 毫米。用从左侧收获的自体移植物重建右腓神经，作为对照。手术后，结缔组织从 PGA 胶原蛋白管的两个切口延伸出来，并在中心再次连接。病理上，管内的胶原海绵为神经组织延伸提供了足够的支架，神经组织在3周内重新连接。电生理方面，术后18天检测肌肉诱发电位（MEP）和复合神经动作电位（CNAP）。术后长达 6 个月，PGA 胶原蛋白侧的 CNAP 和体感诱发电位 (SEP) 比自体移植侧的潜伏期更短，峰值电压更大。 PGA 侧的有髓轴突直径大于自体移植侧的有髓轴突。研究表明，PGA 胶原管有可能成为传统自体移植的有效替代品，用于修复某些周围神经缺损。 (C) 2004 Elsevier B.V. 保留所有权利。
We have developed a bioabsorbable polyglycolic, acid (PGA) tube filled with collagen sponge (PGA-collagen tube) as a nerve connective guide, and compared its effectiveness with that of autograft in terms of nerve regeneration across a gap. The PGA-collagen tube was implanted into 24 beagle dogs across a 15-mm gap in the left peroneal nerve. The right peroneal nerve was reconstructed with the autograft harvested from the left side, as a control. After the surgery, the connective tissue extended from both cut ends in the PGA-collagen tube and connected again at the center. Pathologically, the collagen sponge in the tube provided adequate scaffolding for nerve tissue extension, and the nerve tissue reconnected within 3 weeks. Electrophysiologically, muscle-evoked potentials (MEPs) and compound nerve action potentials (CNAPs) were detected 18 days after the surgery. For up to 6 months postsurgery, CNAPs and somatosensory-evoked potentials (SEPs) on the PGA-collagen side had a shorter latency and larger peak voltage than those on the autograft side. The myelinated axons on the PGA side were larger in diameter than those on the autograft side. It is suggested that the PGA-collagen tube has the potential to be an effective alternative to conventional autografting for the repair of some peripheral nerve defects. (C) 2004 Elsevier B.V. All rights reserved.