Engulfment is required for cell competition
Engulfment is required for cell competition
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DOI：
10.1016/j.cell.2007.03.054
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发表时间：
2007-06-15
期刊：
影响因子：
64.5
通讯作者：
Baker, Nicholas E.
中科院分区：
文献类型：
--
作者：
Li, Wei;Baker, Nicholas E.
将细胞置于组织内相互竞争的遗传马赛克可以模拟组织修复和肿瘤发展的特征，并可能揭示生长调节机制。在一个例子中，正常细胞消除了核糖体蛋白基因剂量减少的“微小”细胞，并以它们为代价生长，取而代之的是发育中的间隔内的微小细胞。我们描述了野生型细胞杀死果蝇微小邻居所需的基因。吞噬基因Draper、Wasp、磷脂酰丝氨酸受体、MBC/dock180和rac1在野生型细胞中是需要的，以应对微小邻居的死亡，因为他们的身体被野生型细胞吞噬。野生型细胞本身会被吞噬活性增强的细胞杀死。因此，吞噬基因作用于细胞间生长差异的下游，以减少核糖体基因剂量来消除细胞。
Genetic mosaics that place cells in competition within tissues may model features of tissue repair and tumor development and may reveal mechanisms of growth regulation. In one example, normal cells eliminate "Minute" cells that have reduced ribosomal protein gene dose and grow at their expense, replacing the Minute cells within developing compartments. We describe genes that are required by wild-type cells to kill Minute neighbors in Drosophila. The engulfment genes draper, wasp, the phosphatidylserine receptor, mbc/dock180, and rac1 are needed in wild-type cells for the death of Minute neighbors, whose corpses are engulfed by wild-type cells. Wild-type cells can themselves be killed by cells with elevated engulfing activity. Thus engulfment genes act downstream of growth differences between cells to eliminate cells with reduced ribosomal gene dose.