Selection and sticklebacks
Selection and sticklebacks
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DOI：
10.1111/j.1365-294x.2008.03863.x
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发表时间：
2008-08-01
影响因子：
4.9
通讯作者：
Beaumont, Mark A.
中科院分区：
文献类型：
--
作者：
Beaumont, Mark A.
在过去的十年里，有越来越多的间接证据表明基因组中的自然选择作用，主要来自对大量标记的分子遗传学调查。在没有密集定位标记的非模式生物中，一种常用的方法是鉴定相对于其他种群具有异常高或低水平遗传分化或低遗传多样性的基因座。Makinen et al.（2008a）在本期《分子生态学》上发表的论文报告了对七个三棘鱼种群100多个微卫星等位基因频率的调查结果。他们表明，位于Eda基因内含子内的一个微卫星位点和两个indel标记，已知控制棘鱼侧板的数量（图1），倾向于比其他位点更高的遗传分化，这一发现与局部选择的作用一致。他们确定了另外两个独立的候选人进行本地选择，最有趣的是，他们进一步表明，多达15%的基因座可能提供平衡选择的证据。
Over the last decade, there has been increasing circumstantial evidence for the action of natural selection in the genome, arising largely from molecular genetic surveys of large numbers of markers. In nonmodel organisms without densely mapped markers, a frequently used method is to identify loci that have unusually high or low levels of genetic differentiation, or low genetic diversity relative to other populations. The paper by Makinen et al. (2008a) in this issue of Molecular Ecology reports the results of a survey of microsatellite allele frequencies at more than 100 loci in seven populations of the three-spined stickleback (Gasterosteus aculeatus). They show that a microsatellite locus and two indel markers located within the intron of the Eda gene, known to control the number of lateral plates in the stickleback (Fig. 1), tend to be much more highly genetically differentiated than other loci, a finding that is consistent with the action of local selection. They identify a further two independent candidates for local selection, and, most intriguingly, they further suggest that up to 15% of their loci may provide evidence of balancing selection.