Decreased Fos protein expression in rat caudal vestibular nucleus is associated with motion sickness habituation
Decreased Fos protein expression in rat caudal vestibular nucleus is associated with motion sickness habituation
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大鼠前庭尾核 Fos 蛋白表达减少与晕动病习惯相关
DOI：
10.1016/j.neulet.2010.06.011
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发表时间：
2010-08-09
影响因子：
2.5
通讯作者：
Guo, Jun-Sheng
中科院分区：
文献类型：
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作者：
Cai, Yi-Ling;Wang, Jun-Qin;Guo, Jun-Sheng
我们研究了每天2小时类似摩天轮（FWL）旋转的大鼠前庭尾部核Fos蛋白表达的时间变化。重复轮换（每天2小时，连续14天）导致排便量最初增加，随后在8轮轮换后逐渐下降到基线水平。与排便不同，大鼠的高岭土消耗在每日轮换时段（每天2 h，连续33天）中表现出啃噬功能，并在约31次轮换后恢复到基线水平。免疫组化研究显示，前庭内侧核和脊髓前庭核中Fos免疫标记（Fos- li）神经元在最初的7次旋转中增加，在10次旋转后下降到基线水平。在整个轮转过程中，Fos-LI神经元数量与大鼠排便水平呈较强的线性关系。这些结果提示，在晕动病习惯化过程中，前庭核尾侧神经元可塑性的改变可能有助于减轻胃肠道症状。2010爱思唯尔爱尔兰有限公司版权所有。
We investigated the temporal change of Fos protein expression in the caudal vestibular nucleus of rats exposed to daily 2-h Ferris-wheel like (FWL) rotation. Repeated rotation (2 h daily for 14 consecutive days) caused an initial increase in defecation, followed by a gradual decline back to the baseline level after 8 rotation sessions. Unlike defecation, the Kaolin consumption of rats showed a bitonic function during the daily rotation sessions (2 h daily for 33 consecutive days) and finally recovered to the baseline after about 31 sessions. Immunohistochemistry study revealed increased Fos immunolabeled (Fos-LI) neurons in the medial vestibular nucleus and spinal vestibular nucleus during the initial 7 rotation sessions, and it decreased to the baseline level after 10 rotation sessions. There was a strong linear relationship between the amount of Fos-LI neurons and rat defecation level throughout the whole rotation sessions. These results suggest that the change of neuronal plasticity in the caudal vestibular nucleus might contribute to attenuation of gastrointestinal symptoms during motion sickness habituation process. (C) 2010 Elsevier Ireland Ltd. All rights reserved.