Insect calcium channels. Molecular cloning of an alpha 1-subunit from housefly (Musca domestica) muscle.

Insect calcium channels. Molecular cloning of an alpha 1-subunit from housefly (Musca domestica) muscle.
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昆虫钙通道。

DOI：
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发表时间：
1994
期刊：
FEBS Letters
影响因子：
3.5
通讯作者：
H. Glossmann
H. Glossmann
中科院分区：
生物学3区
文献类型：
--
作者：
M. Grabner;A. Bachmann;F. Rosenthal;J. Striessnig;C. Schultz;D. Tautz;H. Glossmann

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家蝇（Musca Domestica）幼虫的无脊椎动物钙通道α1亚基（称为Mdlα1）的完整氨基酸序列已通过cDNA克隆和序列分析推导出来。与 DHP 不敏感的钙通道相比，Mdl α 1 与 1,4-二氢吡啶 (DHP) 敏感的 L 型具有更高的序列同一性百分比。如整体原位杂交和免疫染色所示，Mdl α 1 主要在幼虫体壁肌肉组织中表达。
The complete amino acid sequence of an invertebrate calcium channel alpha 1-subunit from housefly (Musca domestica) larvae (designated Mdl alpha 1) has been deduced by cDNA cloning and sequence analysis. Mdl alpha 1 shares higher percent sequence identity with 1,4-dihydropyridine (DHP)-sensitive L-type than with DHP-insensitive calcium channels. As shown by whole mount in situ hybridization and immunostaining Mdl alpha 1 is predominantly expressed in the larval body wall musculature.