Novel treatment strategies in rheumatoid arthritis
Novel treatment strategies in rheumatoid arthritis
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DOI：
10.1016/s0140-6736(17)31491-5
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发表时间：
2017-06-10
期刊：
影响因子：
168.9
通讯作者：
Pope, Janet E.
中科院分区：
文献类型：
--
作者：
Burmester, Gerd R.;Pope, Janet E.
新的治疗策略极大地改变了类风湿关节炎的病程。如果及早发现疾病并及时、持续治疗，许多患者可以获得缓解；然而，有些人对治疗反应不充分。快速诊断和针对性治疗以及严格监测和控制可以增加类风湿关节炎患者缓解的可能性。在本系列论文中，我们描述了使用经典和新型药物的靶向治疗方法治疗类风湿关节炎的新见解，并概述了精准医疗在这种具有挑战性的疾病中的潜在效果。其中包括研究治疗目标方法的文章，其中包括增加或减少治疗。类风湿性关节炎的治疗因延迟诊断、难以接触专家以及难以遵守目标治疗原则而受到阻碍。类风湿性关节炎的临床管理目标包括快速获得最佳诊断和护理以及充分知情地使用已批准用于该疾病的多种治疗方法。
New treatment strategies have substantially changed the course of rheumatoid arthritis. Many patients can achieve remission if the disease is recognised early and is treated promptly and continuously; however, some individuals do not respond adequately to treatment. Rapid diagnosis and a treat-to-target approach with tight monitoring and control, can increase the likelihood of remission in patients with rheumatoid arthritis. In this Series paper, we describe new insights into the management of rheumatoid arthritis with targeted therapy approaches using classic and novel medications, and outline the potential effects of precision medicine in this challenging disease. Articles are included that investigate the treat-to-target approach, which includes adding or de-escalating treatment. Rheumatoid arthritis treatment is impeded by delayed diagnosis, problematic access to specialists, and difficulties adhering to treat-to-target principles. Clinical management goals in rheumatoid arthritis include enabling rapid access to optimum diagnosis and care and the well informed use of multiple treatments approved for this disease.