Inflammatory Bowel Diseases 1990
Inflammatory Bowel Diseases 1990
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炎症性肠病 1990
DOI：
--
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
R. H. Riddell
中科院分区：
文献类型：
--
作者：
Inflammatory Bowel;D. Rachmilewitz;R. H. Riddell
有大量证据表明，遗传因素在炎症性肠病（IBD）、克罗恩病（CD）和溃疡性结肠炎（UC）的易感性中起作用，甚至可能是最重要的作用。证据线包括疾病频率的种族差异，家族聚集性，配偶和双胞胎研究，以及以IBD为特征的遗传综合征的存在。事实上，通过结合遗传标记和基于家庭的生理学研究，一些负责任的基因正在被识别出来。最好的证据存在于HLA和补体系统。重要的生理异常正在检查自身抗体，渗透性和结肠粘蛋白。为了进一步取得这些进展，并利用现代连锁技术和人类基因定位的力量，正在建立IBD家族细胞系定位的国际登记处。IBD易感性存在大量遗传因素，这意味着病原学研究必须考虑遗传因素。遗传研究将有助于描述lBD的基本病因，这将导致新的治疗方法，并最终提供识别疾病预防风险最高的人的手段。1. Ibd是一种遗传性疾病。种族和家族聚集。有关IBD的流行病学数据表明，不同地理区域和种族群体之间的疾病频率存在显著差异。家族聚集性，即亲属中疾病发生率的增加也有充分的记录。这些数据表明，但它们本身并不能证明，遗传因素可能在IBD的病因中起作用。从遗传学的角度来看，最有趣的流行病学观察可能是美国、欧洲和南非的犹太人与这些地区的普通人群相比，患病率相对较高的报告（1-3）。然而，犹太人患IBD的频率，虽然通常比他们居住的一般人群高得多，但在犹太人口中不同的历史种族亚群之间也有所不同。
There is substantial evidence that genetic factors playa role, possibly even the preeminent role, in the predisposition to the inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC). The lines of evidence include ethnic differences in disease frequency, familial aggregation, spouse and twin studies, and the existence of genetic syndromes that feature IBD. Indeed, some of the responsible genes are being identified, by a combination of genetic marker and family based physiologic studies. The best evidence exists for the HLA and complement systems. Important physiologic abnormalities being examined autoantibodies, permeability, and colonic mucins. To further these advances, and to utilize the power of modern linkage technology and human gene mapping, an international registry of mapping cell lines from IBD families is being established. The existence of a substantial genetic component to IBD susceptibility means that etiologic studies must include a consideration of the genetic components. Genetic studies will aid in the delineation of the basic etiologies of lBD, which should lead to new therapies, and will eventually provide the means to identify those at highest risk for disease prevention. 1. IBD IS A GENETIC DISEASE I 1.1. Ethnic and familial aggregation. Epidemiologic data regarding IBD demonstrate dramatic differences in disease frequency between geographic areas and ethnic groups. Familial aggregation, i.e. an increased occurrence of disease in relatives is also well documented. These data suggest, but by themselves do not prove, that genetic factors may playa role in the etiology of IBD. From a genetic point of view, perhaps the most interesting epidemiologic observations are the reports of comparatively higher prevalence rates for the Jewish populations in the USA, Europe, and South Africa, in comparison with those of the general population in these areas (1-3). However, the frequency of IBD among Jews, although usually considerably higher than in the general population in which they reside, varies as well among the different historical ethnic subgroups within the Jewish population.
谷氨酰胺和表皮生长因子对大鼠肠道的联合作用。
影响因子：
3.8
作者：
Jacobs,DO;Evans,DA;Mealy,K;O'Dwyer,ST;Smith,RJ;Wilmore,DW
通讯作者：
Wilmore,DW
小剂量口服甲氨蝶呤治疗银屑病后出现全血细胞减少。
DOI：
--
发表时间：
1988
期刊：
JAMA : the journal of the American Medical Association
影响因子：
--
作者：
Shupack,JL;Webster,GF
通讯作者：
Webster,GF
DOI：
10.1056/nejm198105143042005
发表时间：
1981
期刊：
The New England journal of medicine
影响因子：
--
作者：
Johnson,RA;Baker,SS;Fallon,JT;Maynard3rd,EP;Ruskin,JN;Wen,Z;Ge,K;Cohen,HJ
通讯作者：
Cohen,HJ