MODULATION OF LAMPREY FICTIVE SWIMMING AND MOTONEURON PHYSIOLOGY BY DOPAMINE, AND ITS IMMUNOCYTOCHEMICAL LOCALIZATION IN THE SPINAL-CORD
MODULATION OF LAMPREY FICTIVE SWIMMING AND MOTONEURON PHYSIOLOGY BY DOPAMINE, AND ITS IMMUNOCYTOCHEMICAL LOCALIZATION IN THE SPINAL-CORD
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DOI：
10.1016/0304-3940(94)90831-1
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发表时间：
1994-01-17
影响因子：
2.5
通讯作者：
KEMNITZ, CP
中科院分区：
文献类型：
--
作者：
MCPHERSON, DR;KEMNITZ, CP
采用多巴胺抗体检测了七鳃鳗脊髓多巴胺免疫反应性（DA-IR）的分布。这显示了一群位于中央管略腹侧的小细胞，突起延伸到中央管。细胞的腹侧是稀疏的DA-IR纤维丛。在谷氨酸诱导的有效游泳过程中，在0.1-1 μ M时使用DA可使循环速率加快，但在较高浓度（10 μ M-1 mM）时，循环速率减慢。在脊髓运动神经元上泡浴或压力喷射DA可使动作电位后期后超极化期减少40-50%，而不影响输入电阻、膜电位、动作电位振幅或持续时间。
The distribution of dopamine immunoreactivity (DA-IR) in lamprey spinal cord was examined using antibodies to dopamine. This revealed a population of small cells slightly ventral to the central canal, with processes extending to it. Ventral to the cells is a sparse plexus of DA-IR fibers. Bath application of DA during glutamate-induced fictive swimming caused cycle rate acceleration at 0.1-1 mu M, but slowed the rhythm at higher concentration tions (10 mu M-1 mM). Bath application or pressure ejection of DA onto spinal motoneurons reduced the late afterhyperpolarization phase of action potentials by 40-50%, without affecting input resistance, membrane potential, or action potential amplitude or duration.