The evaluation of a deformable image registration segmentation technique for semi-automating internal target volume (ITV) production from 4DCT images of lung stereotactic body radiotherapy (SBRT) patients
The evaluation of a deformable image registration segmentation technique for semi-automating internal target volume (ITV) production from 4DCT images of lung stereotactic body radiotherapy (SBRT) patients
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DOI：
10.1016/j.radonc.2010.12.007
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发表时间：
2011-02-01
影响因子：
5.7
通讯作者：
Thwaites, David
中科院分区：
文献类型：
--
作者：
Speight, Richard;Sykes, Jonathan;Thwaites, David
目的：为了评估一种变形图像配准（RDT）分割技术的半自动ITV生产从4DCT肺patients.Methods的准确性和效率：25立体定向体放射治疗肺患者被选中在这项回顾性研究。ITV由肿瘤学家手动描绘，并通过使用商业软件，使用两种不同的并行算法将在通气中期手动描绘的GTV传播到所有其他阶段来半自动产生。使用骰子相似系数（DSC），一致性和归一化DSC之间的平均距离，将由ESTA产生的两个ITV与手动描绘的ITV进行比较。DIR生产的ITVs进行了评估，他们的临床适用性和节省的时间进行了estimated.Results：18的25 ITVs已归一化DSC> 1表示与手动生产的ITV在1毫米的不确定性协议。其他7个ITV中的4个被认为是临床可接受的，3个需要少量编辑。一般来说，ITV产生的自动绘图比那些产生的手动划定更顺利。据估计，使用这种技术将节省临床医生平均28 min/patient.Conclusions：ABAS被认为是一个有用的工具，在生产ITVs的肺部患者。所产生的ITV要么是立即临床上可接受的，要么需要最少的编辑。这种方法为临床医生节省了大量时间。(C)2010爱思唯尔爱尔兰有限公司版权所有。放射治疗和肿瘤学98（2011）277 - 283
Purpose: To evaluate a deformable image registration (DIR) segmentation technique for semi-automating ITV production from 4DCT for lung patients, in terms of accuracy and efficiency.Methods: Twenty-five stereotactic body radiotherapy lung patients were selected in this retrospective study. ITVs were manually delineated by an oncologist and semi-automatically produced by propagating the GTV manually delineated on the mid-ventilation phase to all other phases using two different DIR algorithms, using commercial software. The two ITVs produced by DIR were compared to the manually delineated ITV using the dice similarity coefficient (DSC), mean distance between agreement and normalised DSC. DIR-produced ITVs were assessed for their clinical suitability and also the time savings were estimated.Results: Eighteen out of 25 ITVs had normalised DSC > 1 indicating an agreement with the manually produced ITV within 1 mm uncertainty. Four of the other seven ITVs were deemed clinically acceptable and three would require a small amount of editing. In general, ITVs produced by DIR were smoother than those produced by manual delineation. It was estimated that using this technique would save clinicians on average 28 min/patient.Conclusions: ABAS was found to be a useful tool in the production of ITVs for lung patients. The ITVs produced are either immediately clinically acceptable or require minimal editing. This approach represents a significant time saving for clinicians. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 98 (2011) 277-283