Idiotypic interactions in immune responses to tumor-associated antigens.
Idiotypic interactions in immune responses to tumor-associated antigens.
复制标题
对肿瘤相关抗原的免疫反应中的独特型相互作用。
DOI：
10.1016/0304-419x(86)90025-9
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Nepom,GT
中科院分区：
文献类型：
--
作者：
Lee,VK;Hellström,KE;Nepom,GT
* 地址：Virginia Mason Research Center，1000 Seneca St.，西雅图，WA 98101，USA缩写：MAb，单克隆抗体; TAA，肿瘤相关抗原; Id，独特型;抗Id，抗独特型抗体; IG，免疫球蛋白; DTH，迟发型超敏反应; TS，抑制性T细胞; KLH，锁眼帽贝血蓝蛋白; CRI，交叉反应独特型; TMV，烟草花叶病毒; SV 40，猿猴病毒40; HRP，辣根过氧化物酶; LAI，白细胞粘附抑制，BTCC，膀胱移行细胞癌; MCA，3-甲基胆蒽。通讯地址：Dr. VK Lee，ONCOGEN，3005 First Avenue，西雅图，WA 98121，USA。I.肿瘤特异性移植抗原的存在早在30多年前就在实验诱导的动物肿瘤中得到证实[1-4]。在随后的几年中，越来越多的证据表明人类肿瘤也表达肿瘤抗原，因为癌症患者有时会对其自体肿瘤产生免疫反应[5，6]。然而，靶向抗-
* Present address: Virginia Mason Research Center, 1000 Seneca St., Seattle, WA 98101, USA Abbreviations: MAb, monoclonal antibodies; TAA, tumor-associated antigens; Id, idiotype; anti-Id, anti-idiotypic antibodies; Ig, immunoglobulin; DTH, delayed-type hypersensitivity; Ts, suppressor T cells; KLH, keyhole limpet hemocyanin; CRI, cross-reactive idiotype; TMV, tobacco mosaic virus; SV40, simian virus 40; HRP, horseradish peroxidase; LAI, leukocyte adherence inhibition BTCC, bladder transitional cell carcinoma; MCA, 3-methylcholanthrene. Correspondence address: Dr. VK Lee, ONCOGEN, 3005 First Avenue, Seattle, WA 98121, USA. i. IntroductionThe existence of tumor-specific transplantation antigens was demonstrated more than 30 years ago in experimentally-induced animal tumors [1-4]. During the subsequent years, evidence has accumulated suggesting that human neoplasms also express tumor antigens, since cancer patients sometimes mount immunological responses to their autologous tumors [5, 6]. However, the molecular nature and tissue distribution of the target anti-