Evaluation of serum zinc level in patients with newly diagnosed and resistant alopecia areata
Evaluation of serum zinc level in patients with newly diagnosed and resistant alopecia areata
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DOI：
10.1111/ijd.12769
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发表时间：
2016-01-01
影响因子：
3.6
通讯作者：
Al-Qaradaghi, Suzan M. Q.
中科院分区：
文献类型：
--
作者：
Fattah, Nermeen S. A. Abdel;Atef, Mona M.;Al-Qaradaghi, Suzan M. Q.
斑秃（Alopecia areata，AA）是一种非瘢痕性、自身免疫性、炎性脱发疾病。锌是一种参与毛囊重要功能活动的微量元素。目的评价新诊断和耐药AA患者血清锌水平，并与年龄和性别匹配的健康对照组进行比较。50例AA患者分为两个平均分布的亚组（25例近期发作AA患者[亚组1]和25例耐药AA患者[亚组2]）和50例年龄和性别匹配的健康对照。所有受试者的血清锌水平进行了评估。比较所有患者与对照组之间、患者亚组之间以及患者亚组与对照组之间的平均血清锌水平。结果AA患者血清锌水平明显低于对照组，AA耐药患者血清锌水平明显低于新诊断的AA患者。结论AA患者血清锌水平较低，且与病程、病情严重程度及对治疗的抵抗性呈负相关。因此，AA患者血清锌水平的评估似乎是有用的严重程度，疾病的持续时间和耐药性的治疗标志物。因此，锌补充剂可以提供治疗益处。
Background Alopecia areata (AA) is a non-scarring, autoimmune, inflammatory hair loss disease. Zinc is a trace element involved in important functional activities of hair follicles.Purpose To evaluate serum zinc levels in patients with newly diagnosed and resistant lesions of AA in comparison to age-and sex-matched healthy controls.Methods The present study included 100 subjects: 50 patients with AA divided into two equally distributed subgroups (25 patients with recent onset AA [subgroup 1] and 25 patients with resistant AA [subgroup 2]) and 50 age-and sex-matched healthy controls. Serum zinc levels were assessed in all subjects. Comparison of mean serum zinc levels was done between all patients and controls, between patients' subgroups as well as between patient's subgroup and controls. Correlations between serum zinc level and extent of AA and its duration were also done in all patients and each patient's subgroup.Results A significantly lower serum zinc level was found in patients with AA compared with controls and was significantly lower in patients with resistant AA compared to patients with newly diagnosed AA. Significant inverse correlations existed between serum zinc level, severity of AA, and disease duration in all patients as well as in patients with resistant AA.Conclusion Lower serum zinc level existed in patients with AA and correlated inversely with disease duration, severity of AA, and its resistance to therapies. Therefore, assessment of serum zinc level in patients with AA appears useful as a marker of severity, disease duration, and resistance to therapies. Accordingly, zinc supplements may provide a therapeutic benefit.