Palindromes and genomic stress fractures:: Bracing and repairing the damage
Palindromes and genomic stress fractures:: Bracing and repairing the damage
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DOI：
10.1016/j.dnarep.2006.05.014
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发表时间：
2006-09-08
期刊：
影响因子：
3.8
通讯作者：
Cote, Atina G.
中科院分区：
文献类型：
--
作者：
Lewis, Susanna M.;Cote, Atina G.
DNA回文序列是真核生物基因组不稳定性的来源，但由于难以研究，因此仍未得到充分研究。尽管如此，在过去的一年左右的进展已经开始形成一个连贯的画面，DNA回文如何导致真核生物的损害，以及这种损害是如何对抗细胞机制。在酵母中，在体内回文位点出现的双链DNA中断的特征表明，消退酶型活性通过在回文挤出成十字形后攻击回文来产生断裂。结构以这种方式诱导DNA断裂可以通过在小鼠中详细研究的中心断裂回文修正过程来阻止。MRX/MRN可能在防止真核生物中回文诱导的基因组损伤中起关键作用。(c)2006 Elsevier B. V.保留所有权利。
DNA palindromes are a source of instability in eukaryotic genomes but remain under-investigated because they are difficult to study. Nonetheless, progress in the last year or so has begun to form a coherent picture of how DNA palindromes cause damage in eukaryotes and how this damage is opposed by cellular mechanisms. In yeast, the features of double strand DNA interruptions that appear at palindromic sites in Vivo suggest that a resolvase-type activity creates the fractures by attacking a palindrome after it extrudes into a cruciform. structure. Induction of DNA breaks in this fashion could be deterred through a Center-Break palindrome revision process as investigated in detail in mice. The MRX/MRN likely plays a pivotal role in prevention of palindrome-induced genome damage in eukaryotes. (c) 2006 Elsevier B.V. All rights reserved.