Gastric stasis in migraine: More than just a paroxysmal abnormality during a migraine attack
Gastric stasis in migraine: More than just a paroxysmal abnormality during a migraine attack
复制标题
DOI：
10.1111/j.1526-4610.2006.00311.x
复制
发表时间：
2006-01-01
期刊：
影响因子：
5
通讯作者：
Haseley, D
中科院分区：
文献类型：
--
作者：
Aurora, SK;Kori, SH;Haseley, D
目的：-本文的目的是评估偏头痛发作期和发作间期的胃动力和胃排空。背景-恶心是偏头痛的主要症状，其基础被认为是胃停滞。然而，缺乏客观的方法来确定这一点。我们利用胃核素研究来确定偏头痛发作期和发作间期的胃运动。方法：10名偏头痛受试者与年龄和性别匹配的同等数量的对照组进行比较。在发作期对所有对照受试者和所有10名偏头痛受试者进行了一次胃核素扫描，并在发作期进行了9项研究。结果：使用本机构的标准数据，偏头痛发作期(78%)和发作期(80%)半排空时间延迟。胃停滞在发作间歇期(149.9分钟)与发作间期(188.8分钟)相比不那么明显。与非偏头痛对照组相比有显著的延迟(偏头痛188.8分钟与正常对照组111.8分钟；P<；0.05)。这些数据在2小时后残留在胃中的放射性物质的百分比上得到了复制。结论：与之前的看法相反，这项研究表明，偏头痛患者在急性偏头痛发作期间和发作之外都会出现胃停滞。这可能表明，与非偏头痛对照组相比，偏头痛患者的自主神经功能可能异常。这在偏头痛的病理生理学中的潜在作用被讨论，并探索了进一步研究的途径。
Objective.-The aim of this article is to evaluate gastric motility and emptying in the ictal and interictal period in migraine.Background.-Nausea is a predominant symptom of migraine and the basis of it is thought to be gastric stasis. Objective methods to establish this are however lacking. We utilized gastric scintigraphy studies to determine gastric motility in the ictal and interictal period of migraine.Methods.-Ten migraine subjects were compared to equal number of age and sex matched controls. Gastric scintigraphy using a standard meal was performed in all control subjects once and in all 10 migraine subjects in the interictal period and nine studies were performed in the ictal period migraine.Results.-The time to half emptying was delayed in migraine ictally (78%) and interictal period (80%) using normative data at this institution. Gastric stasis was less pronounced ictally (149.9 minutes) compared to interictal period (188.8 minutes). There was a significant delay compared to nonmigrainous controls (migraine 188.8 minutes vs normal controls 111.8 minutes; P < .05). These data were replicated in percentage of radioactive material remaining in the stomach at 2 hours.Conclusions.-Contrary to previous belief, this study has demonstrated that migraineurs suffer from gastric stasis both during and outside an acute migraine attack. This may suggest that migraineurs may have an abnormal autonomic function compared to nonmigrainous controls. The potential role of this in pathophysiology of migraine is discussed and avenues for further investigations are explored.