The glomerular transcriptome and Proteome
The glomerular transcriptome and Proteome
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DOI：
10.1159/000101790
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Tryggvason, Karl
中科院分区：
文献类型：
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作者：
Betsholtz, Christer;He, Liqun;Tryggvason, Karl
组织病理学为肾小球疾病的分类和诊断提供了当前的基础。分子谱分析方法，如mRNA表达的微阵列分析，在过去几年迅速出现，现在适用于微量的组织材料，如胚胎或成年实验动物的肾小球，或来自人类肾穿刺活检。本文综述了目前在发育、健康成人和疾病中肾小球转录组和蛋白质组测定方面的研究成果。这些研究令人鼓舞，并表明肾小球的全面分子图谱将最有可能为肾小球滤过器的正常结构和功能、肾小球发育的分子机制、肾小球疾病的诊断和分类以及伴随几种常见全体性疾病的肾小球滤过器功能逐步破坏的致病机制提供重要的新见解。版权所有(c) 2007 S. Karger AG，巴塞尔。
Histopathology provides the current basis for classification and diagnosis of glomerular disorders. Molecular profiling methods, such as microarray analysis of mRNA expression, have rapidly emerged over the past years and are now applicable to minute amounts of tissue material, such as glomeruli from embryos or adult experimental animals, or from human renal needle biopsies. This review summarizes current efforts aiming at the determination of the glomerular transcriptome and proteome during development, in the healthy adult, and in disease. These studies are encouraging and show that comprehensive molecular profiling of the kidney glomerulus will most likely provide significant new insights into the normal structure and function of the glomerular filter, the molecular mechanisms of glomerular development, the diagnosis and classification of glomerular disease, and the pathogenic mechanisms underlying the stepwise breakdown of glomerular filter function that accompanies several common systemic disorders. Copyright (c) 2007 S. Karger AG, Basel.