Relationship between Proinflammatory Cytokines/Chemokines and Adipokines in Serum of Young Adults with Obesity
Relationship between Proinflammatory Cytokines/Chemokines and Adipokines in Serum of Young Adults with Obesity
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DOI：
10.2174/1871530318666180131094733
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发表时间：
2018-01-01
影响因子：
1.9
通讯作者：
de Abreu, Luiz C.
中科院分区：
文献类型：
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作者：
Borges, Maraisa D.;Franca, Eduardo L.;de Abreu, Luiz C.
背景和目的：脂肪组织被认为是一种重要的内分泌器官，具有代谢活性，表达和分泌多种炎性细胞因子。炎症与肥胖相关的并发症有关。方法：根据体重指数(BMI)将30例肥胖者分为3组：肥胖组(GC，n=10)、超重组(GOW，n=10)和肥胖组(GOB，n=10)。测定血糖、总胆固醇、高密度脂蛋白胆固醇、甘油三酯、总蛋白、尿酸和胰岛素，以及细胞因子IL-8、IL-6、瘦素和脂联素。结果：GOB的血糖、总胆固醇、甘油三酯、尿酸、胰岛素、瘦素、IL-8、IL-1β、IL-6、TNF-α和脂联素水平最高，而脂联素水平最低。总体而言，脂联素与BMI、腹围、低密度脂蛋白、IL-6、肿瘤坏死因子-α、瘦素、瘦素/脂联素比值呈负相关，与高密度脂蛋白呈正相关。瘦素与BMI、腹围、胰岛素、IL-6、TNF-α、LAR呈正相关，与高密度脂蛋白、脂联素呈负相关。LAR与BMI、腰围、胰岛素、肿瘤坏死因子-α呈正相关，与高密度脂蛋白-C呈负相关。结论：肥胖改变了个体的血脂和血糖谱，增加了促炎性脂肪因子水平，降低了抗炎性脂肪因子水平，促进了慢性炎症状态。
Background and Objective: The adipose tissue has been recognized as an important endocrine organ, which is metabolically active and expresses and secretes various inflammatory cytokines. Inflammation is involved in obesity-related complications. As such, the present study investigated the correlation between biochemical parameters, serum proinflammatory cytokines and adipokines in individuals with obesity.Methods: Based on the body mass index (BMI), 30 subjects were divided into 3 groups: eutrophic (GC, n = 10), overweight (GOW, n = 10) and obese (GOB, n = 10). Serum glucose, cholesterol (total-C, HDLC and LDL-C), triglycerides, total proteins, uric acid and insulin were determined, as well as cytokines IL-8, TNF-alpha, IL-1 beta, and IL-6, leptin and adiponectin.Results: GOB showed the highest glucose, total and LDL-C, triglycerides, uric acid, insulin, leptin, IL-8, IL-1 beta, IL-6, TNF-alpha and lowest adiponectin levels. In general, adiponectin exhibited an inverse correlation with BMI, abdominal circumference, LDL-C, IL-6, TNF-alpha, leptin and leptin-adiponectin ratio (LAR) and a positive correlation with HDL-C. Leptin was positively correlated with BMI, abdominal circumference, insulin, IL-6, TNF-alpha and LAR and negatively correlated with HDL-C and adiponectin. The LAR was positively correlated with BMI, waist circumference, insulin, TNF-alpha and negatively associated with HDL-C.Conclusion: The results confirm that obesity changes the lipid and glycemic profiles of individuals, increases the proinflammatory adipokine levels and reduces those of anti-inflammatory adipokines, promoting a state of chronic inflammation.