A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry
A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry
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DOI：
10.1016/s0378-4347(01)00444-3
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发表时间：
2002-10-05
影响因子：
3
通讯作者：
Needham, LL
中科院分区：
文献类型：
--
作者：
Barr, DB;Barr, JR;Needham, LL
我们开发了一种灵敏、准确的分析方法，用于定量测定人血清或血浆中的29种当代农药。这些农药包括有机磷酸酯、氨基甲酸酯、氯乙酰苯胺和合成拟除虫菊酯等，包括农业和住宅环境中使用的农药。我们的方法采用了一个简单的固相萃取，然后用同位素稀释气相色谱-高分辨率质谱进行高选择性分析。我们的方法非常准确，在低pg/g范围内具有检测限，并且在方法线性范围的低pg/g端的变异系数通常小于20%。我们用这种方法来测量血浆农药浓度的女性生活在城市地区。我们发现检测浓度的西维因/萘，残杀威，bendiocarb，毒死蜱，二嗪农，dicloran，克菌丹和灭菌丹或其代谢物在20%以上的血浆样本测试。出版社：Elsevier Science B. V.
We have developed a sensitive and accurate analytical method for quantifying 29 contemporary pesticides in human serum or plasma. These pesticides include organophosphates, carbamates, chloroacetanilides, and synthetic pyrethroids among others and include pesticides used in agricultural and residential settings. Our method employs a simple solid-phase extraction followed by a highly selective analysis using isotope dilution gas chromatography-high-resolution mass spectrometry. Our method is very accurate, has limits of detection in the low pg/g range and coefficients of variation of typically less than 20% at the low pg/g end of the method linear range. We have used this method to measure plasma pesticide concentrations in females living in an urban area. We found detectable concentrations of carbaryl/naphthalene, propoxur, bendiocarb, chlorpyrifos, diazinon, dicloran, captan and folpet or their metabolites in more than 20% of the plasma samples tested. Published by Elsevier Science B.V.