Development of CD1d-restricted NKT cells in the mouse thymus
Development of CD1d-restricted NKT cells in the mouse thymus
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DOI：
10.1002/eji.200425546
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发表时间：
2004-12-01
影响因子：
5.4
通讯作者：
Sant'Angelo, DB
中科院分区：
文献类型：
--
作者：
Dao, T;Guo, DL;Sant'Angelo, DB
利用遗传和表型分析，我们分析了小鼠cd1限制性不变性NKT细胞的发育途径。我们提供了强有力的证据表明，与传统T细胞相似，NKT细胞的阳性选择发生在CD4（+）和CD8（+）阶段。NKT细胞发育的后期涉及TCR和CD4水平的下调，因此与传统的T细胞发育途径不同。Fyn （Src家族激酶成员）是NKT细胞和传统T细胞群的独特而完全的依赖性。
Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4(+)CD8(+) stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.