THE NEU GENE - AN ERBB-HOMOLOGOUS GENE DISTINCT FROM AND UNLINKED TO THE GENE ENCODING THE EGF RECEPTOR
THE NEU GENE - AN ERBB-HOMOLOGOUS GENE DISTINCT FROM AND UNLINKED TO THE GENE ENCODING THE EGF RECEPTOR
复制标题
DOI：
10.1126/science.2992090
复制
发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
COUSSENS, L
中科院分区：
文献类型：
--
作者：
SCHECHTER, AL;HUNG, MC;COUSSENS, L
在乙基亚硝脲诱导的大鼠神经胶质母细胞瘤中发现的癌基因与编码表皮生长因子受体的erbB基因有很强的同源性。这种同源性仅限于编码酪氨酸激酶结构域的bferB区域。结论：该基因是一个独特的新基因，因为它不与A431肿瘤细胞基因组中编码EGF受体的序列共扩增，它定位在人类17号染色体上。
Theneuoncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with theerbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region oferbB encoding the tyrosine kinase domain. It was concluded that theneugene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.