Diurnal variation in spontaneous eye-blink rate
Diurnal variation in spontaneous eye-blink rate
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DOI：
10.1016/s0165-1781(00)00108-6
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发表时间：
2000-03-06
影响因子：
11.3
通讯作者：
Rinaldi, F
中科院分区：
文献类型：
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作者：
Barbato, G;Ficca, G;Rinaldi, F
研究了24名健康受试者的自发眨眼率（BR）的日常模式，这是一种非侵入性的中枢多巴胺活性外周测量方法。自发眨眼率在上午、中午和下午表现出稳定的模式。在傍晚时间点（20.30小时）发现明显增加。这一发现暗示了深夜中枢多巴胺活动的增加。研究还发现，在同一个晚上的时间点，主观困倦程度也会增加，这个时间点对应于“晚上清醒维持区”或“睡眠禁区”。一种可能的假设是，“睡眠禁区”可能反映了多巴胺介导的激活，这种激活抵消了不断上升的睡眠欲望。多巴胺功能的日变化在药物治疗方案的选择以及生物学和神经心理学参数的评估中都应考虑其作用。(C) 2000爱思唯尔科学爱尔兰有限公司版权所有。
The daily pattern of spontaneous eye-blink rate (BR), a non-invasive peripheral measure of central dopamine activity, was investigated in 24 healthy subjects. The spontaneous eye-blink rate showed a stable pattern in morning, midday and afternoon hours. A significant increase was found at the evening time point (20.30 h). The finding is suggestive of a late evening increase of central dopamine activity. An increased level of subjective sleepiness was also found at the same evening point, at a time corresponding to the 'evening wake maintenance zone' or the 'forbidden zone for sleep'. A possible hypothesis is that the 'forbidden zone for sleep' may reflect a dopamine-mediated activation that counteracts a rising sleep drive. The role of diurnal variation of dopamine function should be considered both in the choice of the drug treatment regimen, and in the evaluation of biological and neuropsychological parameters. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.