Review of the GAS3 Family of Proteins and their Relevance to Cancer.
Review of the GAS3 Family of Proteins and their Relevance to Cancer.
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DOI：
10.1615/critrevoncog.v20.i5-6.140
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发表时间：
2015
影响因子：
--
通讯作者：
Wadehra M
中科院分区：
文献类型：
--
作者：
Ashki N;Gordon L;Wadehra M
四倍蛋白的GAS3家族最近被认为与癌症的进展有关。目前，GAS3家族的6个成员已经在人类和小鼠中被鉴定出来，虽然它们在疾病中的表达不同，但数据表明它们在上皮细胞结构和功能中发挥作用。在这篇综述中，我们重点介绍了涉及疾病发病机制的四种成员的研究，并探讨了家族成员之间的结构相似性。最后，我们讨论了针对PMP22和EMP2等家族成员的影响。
The GAS3 family of tetraspan proteins has recently been implicated in the progression of cancer. Currently, six members of the GAS3 family have been identified in humans and mice, and while their expressions in disease vary, data suggest that they play a role in epithelial cell structure and function. In this review, we highlight the studies implicating four of the members in disease pathogenesis as well as probe the structural similarities between the family members. Finally, the impact of targeting select members of the family such as PMP22 and EMP2 is discussed.