No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk
No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk
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DOI：
10.1007/s10549-009-0589-5
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发表时间：
2010-06-01
影响因子：
3.8
通讯作者：
Brauch, Hiltrud
中科院分区：
文献类型：
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作者：
Andonova, Irena E.;Justenhoven, Christina;Brauch, Hiltrud
乳腺癌是一种复杂的疾病，近年来许多乳腺癌易感基因被鉴定出来，但低表达易感基因的作用尚未完全解决。谷胱甘肽S-转移酶（GSTs）是一类参与化学致癌物和环境污染物解毒的II相代谢酶，在细胞抗氧化应激防御机制中发挥重要作用。他们一直在聚光灯下与乳腺癌风险的潜在关联的调查，但到目前为止，稀疏或甚至没有数据GSTA 2，GSTM 2，GSTO和GSTZ乳腺癌风险的潜在贡献。我们对GSTA2_448_C > G进行了基因分型（rs2180314）、GSTA2_742_A > C（rs6577）、GSTM 2_-832_T > C（rs638820），GSTO1_-1242_G > A（rs2164624）、GST0 1_419_A> C（rs4925）、GST0 2_-183_A > G（rs2297 235），GSTO2_342_A > G（rs156697），GSTZ1_-4378_A > G（rs1046428），和GSTZ1_94_G > A（rs3177427）在德国GENICA乳腺癌病例中通过MAL DI-TOF MS检测-对照收集了1021例病例和1015例对照，并进行了一般乳腺癌风险关联和分层：绝经状态、乳腺癌或卵巢癌家族史、口服避孕药的使用、激素治疗的使用、体重指数和吸烟以及组织病理学肿瘤特征，包括激素受体状态、等级、组织学和淋巴结状态。我们没有观察到任何乳腺癌风险相关性，并得出结论，谷胱甘肽S-转移酶GSTA 2，GSTM 2，GSTO 1，GSTO 2和GSTZ 1不太可能参与乳腺癌易感性。
Breast cancer is a complex disease and in recent years a number of breast cancer susceptibility genes have been identified, but the role of low penetrance susceptibility genes has not been completely resolved. Glutathione S-transferases (GSTs) are phase II xenobiotic metabolizing enzymes involved in the detoxification of chemical carcinogens and environmental pollutants and play an important role in cell defense mechanisms against oxidative stress. They have been in the spot light for the investigation of a potential association with breast cancer risk but so far, sparse or even no data for a potential contribution of GSTA2, GSTM2, GSTO, and GSTZ to breast cancer risk are available. We genotyped GSTA2_448_C > G (rs2180314), GSTA2_742_A > C (rs6577), GSTM2_-832_T > C (rs638820), GSTO1_-1242_G > A (rs2164624), GSTO1_419_A > C (rs4925), GSTO2_-183_A > G (rs2297 235), GSTO2_342_A > G (rs156697), GSTZ1_-4378_A > G (rs1046428), and GSTZ1_94_G > A (rs3177427) by MAL DI-TOF MS in the German GENICA breast cancer case-control collection of 1021 cases and 1015 controls and performed breast cancer risk association in general and with respect to the stratifications: menopausal status, family history of breast or ovarian cancer, use of oral contraceptives, use of hormone therapy, body mass index, and smoking as well as histopathological tumor characteristics including hormone receptor status, grade, histology, and node status. We did not observe any breast cancer risk associations and conclude that it is unlikely that glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 participate in breast cancer susceptibility.