APP Receptor? To Be or Not To Be.
APP Receptor? To Be or Not To Be.
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DOI：
10.1016/j.tips.2016.01.005
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发表时间：
2016-05
影响因子：
13.8
通讯作者：
Parent AT
中科院分区：
文献类型：
--
作者：
Deyts C;Thinakaran G;Parent AT
淀粉样前体蛋白(APP)及其代谢产物在阿尔茨海默病的发病机制中起着重要作用。基于APP与I型跨膜受体在结构上的相似性，以及APP可能的配体的识别，APP可能作为受体发挥作用的想法已经获得了势头。在这里，我们回顾了最近支持这一概念的实验证据，并讨论了该领域如何看待这一概念。具体地说，我们重点介绍了APP作为细胞表面受体的结构和功能特征，以及它与接头和信号蛋白的相互作用。我们还讨论了APP作为阿尔茨海默病病因学受体的重要性，并讨论了这一功能如何可能对开发新的治疗方法具有潜在的重要意义。
Amyloid Precursor Protein (APP) and its metabolites play a critical role in Alzheimer’s disease pathogenesis. The idea that APP may function as a receptor has gained momentum based on its structural similarities to type I transmembrane receptors, and the identification of putative APP ligands. Here we review the recent experimental evidence in support of this notion and discuss how this concept is viewed in the field. Specifically, we focus on the structural and functional characteristics of APP as a cell surface receptor, and its interaction with adaptors and signaling proteins. We also address the importance of APP's function as a receptor in Alzheimer’s disease etiology and discuss how this function might be potentially important for the development of novel therapeutic approaches.