Comparison of fundus fluorescein angiography and fundus photography grading criteria for early diabetic retinopathy.
Comparison of fundus fluorescein angiography and fundus photography grading criteria for early diabetic retinopathy.
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DOI：
10.18240/ijo.2022.02.11
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发表时间：
2022-02
影响因子：
1.4
通讯作者：
Xinyue Li;S. Wang;L. Dong;Hong Zhang
中科院分区：
文献类型：
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作者：
Xinyue Li;S. Wang;L. Dong;Hong Zhang
目的比较眼底照相和荧光素眼底血管造影（fundus fluorescein angiography，FFA）对轻中度非增殖性糖尿病视网膜病变（non-proliferative diabetic retinopathy，NPDR）的诊断价值。方法回顾性分析260例糖尿病患者的眼底照片和FFA检查结果。糖尿病视网膜病变（DR）的严重程度根据国际分类标准进行分级。观察轻至中度NPDR患者的FFA图像中的微动脉瘤、出血和视网膜内微血管异常（IRMA）。对眼底照片与FFA结果的差异进行总结、分析和比较。结果FFA检查发现视网膜内占位性病变仅9只眼（1.9%）在所有四个象限中有超过20个视网膜内病变;（3.1%）三个象限视网膜内病变20个以上，26只眼两个象限内有20个以上视网膜内病变者占5.4%，一个象限内有20个以上视网膜内病变者占7.7%。IRMA ≥4例17眼，3例35眼，2例69眼，1例93眼。结论FFA对视网膜血管病变的诊断准确率高于眼底照相。FFA分级结果有助于眼底照相容易漏诊的病变及时发现和正确治疗。
AIM To compare the assessment outcomes of the characteristics of mild to moderate non-proliferative diabetic retinopathy (NPDR) established by fundus photography and fundus fluorescein angiography (FFA). METHODS The fundus photos and FFA results of 260 patients with diabetes mellitus were reviewed. Diabetic retinopathy (DR) severity was graded based on the international classification standard. The microaneurysms, hemorrhages, and intraretinal microvascular abnormalities (IRMA) in FFA images of patients with mild to moderate NPDR were observed. The differences between the fundus photos and the FFA results were summarized, analyzed, and compared. RESULTS The counting of intraretinal hemorrhages identified by FFA revealed that only 9 eyes (1.9%) had more than 20 intraretinal hemorrhages in all four quadrants; 15 eyes (3.1%) had more than 20 intraretinal hemorrhages in three quadrants; 26 eyes (5.4%) had over 20 intraretinal hemorrhages in two quadrants; and 37 eyes (7.7%) had more than 20 intraretinal hemorrhages in only one quadrant. Furthermore, the number of IRMAs appeared ≥4 in 17 eyes, 3 in 35 eyes, 2 in 69 eyes, and 1 in 93 eyes. CONCLUSION FFA has higher detection accuracy of retinal angiopathy than fundus photography. FFA grading results are helpful for timely detection and proper treatment of lesions easily missed by fundus photography.