Transition-Metal-Free Direct Arylation of Anilines
Transition-Metal-Free Direct Arylation of Anilines
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DOI：
10.1002/anie.201106150
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发表时间：
2012-01-01
影响因子：
16.6
通讯作者：
Greaney, Michael F.
中科院分区：
文献类型：
--
作者：
Pirali, Tracey;Zhang, Fengzhi;Greaney, Michael F.
芳烃芳基化：报道了一种新的苯胺底物直接芳基化反应方法。该反应使用苯炔在温和的条件下合成了各种氨基二芳基(见方案)，不需要化学计量金属化或过渡金属催化。与金属介导的过程相比，烯机制具有很好的官能团耐受性。
Aryne arylation: A new method of direct arylation is reported for aniline substrates. The reaction uses benzyne to synthesize a variety of aminobiaryls under mild conditions (see scheme), requiring no stoichiometric metalation or transition-metal catalysis. An ene mechanism is implicated, and conveys excellent functional group tolerance relative to metal-mediated processes.