Modulation of antibody-mediated immune response by probiotics in chickens
Modulation of antibody-mediated immune response by probiotics in chickens
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DOI：
10.1128/cdli.12.12.1387-1392.2005
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发表时间：
2005-12-01
期刊：
影响因子：
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通讯作者：
Sharif, S
中科院分区：
文献类型：
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作者：
Haghighi, HR;Gong, JH;Sharif, S
益生菌，包括嗜酸乳杆菌和两歧双歧杆菌，已被证明可以增强哺乳动物的抗体反应。本研究的目的是检查除了粪链球菌之外还含有上述细菌的益生菌产品对诱导鸡对各种抗原的抗体应答的影响，包括全身性和肠道中的。通过经口灌胃给鸟接种益生菌，随后用绵羊红细胞（SRBC）和牛血清白蛋白（BSA）免疫以评估血清中的抗体应答，或用破伤风类毒素（TT）免疫以测量肠道内容物中的粘膜抗体应答。对照组接受磷酸盐缓冲盐水。总体而言，BSA和SRBC早在免疫后第1周（p.i.）就诱导了可检测的抗体应答，其持续至p.i.益生菌组的鸡与对照组相比，
Probiotic bacteria, including Lactobacillus acidophilus and Bifidobacterium bifidum, have been shown to enhance antibody responses in mammals. The objective of this study was to examine the effects of a probiotic product containing the above bacteria in addition to Streptococcus faecalis on the induction of the chicken antibody response to various antigens, both systemically and in the gut. The birds received probiotics via oral gavage and subsequently were immunized with sheep red blood cells (SRBC) and bovine serum albumin (BSA) to evaluate antibody responses in serum or with tetanus toxoid (TT) to measure the mucosal antibody response in gut contents. Control groups received phosphate-buffered saline. Overall, BSA and SRBC induced a detectable antibody response as early as week 1 postimmunization (p.i.), which lasted until week 3 p.i. Probiotic-treated birds had significantly (P