Catch up growth in low birth weight infants: Striking a healthy balance
Catch up growth in low birth weight infants: Striking a healthy balance
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DOI：
10.1007/s11154-012-9216-6
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发表时间：
2012-06-01
影响因子：
8.2
通讯作者：
Singhal, Atul
中科院分区：
文献类型：
--
作者：
Jain, Vandana;Singhal, Atul
在出生后最初几个月的追赶性生长几乎普遍存在于出生时小于胎龄的婴儿中，并且通常被认为是非常理想的，因为它消除了生长缺陷。然而，最近这种增长与低收入和高收入国家后期肥胖、胰岛素抵抗和心血管疾病的风险增加有关。在印度，三分之一的婴儿出生时体重不足，但这些婴儿的最佳生长模式尚不确定。为了应对儿童的高传染病发病率、营养不良和发育不良，目前的政策是促进婴儿期的快速成长。然而，随着社会经济转型和城市化使印度的环境更易致胖，2型糖尿病和心血管疾病的患病率不断增加，影响到越来越年轻的人口，婴儿期体重快速/过度增加对后期身体组成和代谢的长期不利影响可能超过短期益处。本综述讨论了上述问题，重点是需要在印度婴儿追赶性生长的风险和益处之间取得健康的平衡。
Catch-up growth in the first few months of life is seen almost ubiquitously in infants born small for their gestational age and conventionally considered highly desirable as it erases the growth deficit. However, recently such growth has been linked to an increased risk of later adiposity, insulin resistance and cardiovascular disease in both low income and high-income countries. In India, a third of all babies are born with a low birth weight, but the optimal growth pattern for such infants is uncertain. As a response to the high rates of infectious morbidities, undernutrition and stunting in children, the current policy is to promote rapid growth in infancy. However, with socio-economic transition and urbanization making the Indian environment more obesogenic, and the increasing prevalence of type 2 diabetes and cardiovascular disease, affecting progressively younger population, the long term adverse programming effect of fast/excessive weight gain in infancy on later body composition and metabolism may outweigh short-term benefits. This review discusses the above issues focusing on the need to strike a healthy balance between the risks and benefits of catch-up growth in Indian infants.