What causes false-negative PET findings for solid-type lung cancer?
What causes false-negative PET findings for solid-type lung cancer?
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DOI：
10.1016/j.lungcan.2012.10.018
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发表时间：
2013-02-01
期刊：
影响因子：
5.3
通讯作者：
Naganawa, Shinji
中科院分区：
文献类型：
--
作者：
Iwano, Shingo;Ito, Shinji;Naganawa, Shinji
背景：为了探讨实质型肺癌PET扫描假阴性的可能原因，我们采用多因素分析的方法，将PET表现与临床和病理特征进行了回顾性比较。方法：我们回顾了PET/CT记录、临床记录、术前薄层CT图像和术后病理记录，选择病变面积为2.5的实体型肺癌为PET阳性。通过Logistic回归分析，在体重、血糖水平、病变大小、部位、组织学类型等5个因素中筛选出PET阳性或阴性的独立预测因素。40个病灶(21.4%)为PET阴性，147个(78.6%)为PET阳性。多因素Logistic回归分析显示，病灶大小(p<；0.001)和组织学类型(p<；0.001)是决定PET检查结果是否阴性的重要因素。结论：在实体型肺癌中，病灶大小和组织病理学表现与浓雾摄取显著相关。尤其值得注意的是，
Background: To investigate possible causes for false-negative findings on PET scans for solid-type lung cancers, we retrospectively compared PET findings to clinical and pathological features using multivariate analysis.Methods: We reviewed PET/CT records, clinical records, preoperative thin-section CT images, and postoperative pathological records and selected only solid-type primary lung cancers with lesions = 2.5 were considered PET-positive. Logistic regression analysis was used to identify independent predictors of PET-positive or negative among five factors: body weight, blood glucose level, lesion size, location, and histological classification.Results: A total of 187 solid-type primary lung cancers were selected. Forty lesions (21.4%) were judged as PET-negative and 147 lesions (78.6%) were judged as PET-positive. Multivariate logistic analysis for the 187 lesions revealed that lesion size (p < 0.001) and histological tumour type (p < 0.001) were significant factors for determining whether PET findings were negative.Conclusions: Among solid-type lung cancers, lesion size and histopathological findings were significantly associated with FOG uptake. In particular, it warrants attention that lesions