Decreased Ebola Transmission after Rapid Response to Outbreaks in Remote Areas, Liberia, 2014.
Decreased Ebola Transmission after Rapid Response to Outbreaks in Remote Areas, Liberia, 2014.
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DOI：
10.3201/eid2110.150912
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发表时间：
2015-10
影响因子：
11.8
通讯作者：
Nyenswah T
中科院分区：
文献类型：
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作者：
Lindblade KA;Kateh F;Nagbe TK;Neatherlin JC;Pillai SK;Attfield KR;Dweh E;Barradas DT;Williams SG;Blackley DJ;Kirking HL;Patel MR;Dea M;Massoudi MS;Wannemuehler K;Barskey AE;Zarecki SL;Fomba M;Grube S;Belcher L;Broyles LN;Maxwell TN;Hagan JE;Yeoman K;Westercamp M;Forrester J;Mott J;Mahoney F;Slutsker L;DeCock KM;Nyenswah T
基本的干预措施和社区的接受可以迅速控制疫情暴发。
我们测量了2014年利比里亚9次疫情中实施干预措施以减少埃博拉传播前后的再生数。我们评估了二代病例的风险因素以及患者进入埃博拉治疗中心（ETU）与存活之间的关联。干预措施开始后，再生数从1.7（95%置信区间1.1 - 2.6）下降了94%，降至0.1（95%置信区间0.02 - 0.6）。进入ETU的患者发生二次感染的风险比在社区死亡的患者低90%（风险比0.1，95%置信区间0.04 - 0.3）。病死率为68%（95%置信区间60 - 74），进入ETU与死亡风险降低50%相关（风险比0.5，95%置信区间0.4 - 0.8）。埃博拉患者的隔离和治疗具有阻断社区传播和提高存活率的双重益处。
Basic interventions and community acceptance can result in rapid control of outbreaks. We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The reproduction number declined 94% from 1.7 (95% CI 1.1–2.6) to 0.1 (95% CI 0.02–0.6) after interventions began. The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04–0.3) than for those who died in the community. The case-fatality rate was 68% (95% CI 60–74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4–0.8). Isolation and treatment of Ebola patients had the dual benefit of interrupting community transmission and improving survival.