An ontology for Xenopus anatomy and development.
An ontology for Xenopus anatomy and development.
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DOI：
10.1186/1471-213x-8-92
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发表时间：
2008-09-25
影响因子：
--
通讯作者：
Vize PD
中科院分区：
文献类型：
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作者：
Segerdell E;Bowes JB;Pollet N;Vize PD
非洲爪蟾和热带爪蟾是产生了丰富的遗传、基因组和发育信息的模式系统。Xenbase是一个模式生物数据库，提供对这些信息的集中访问，包括来自高通量筛选和科学文献的基因功能数据。一个受控的，结构化的爪蟾解剖和发展词汇是组织这些数据的必要条件。我们已经构建了一个爪蟾解剖本体，代表组织的谱系和它们的发展时间。我们将许多解剖特征分类在一个通用框架中，该框架已被多个模式生物数据库社区采用。该本体可在Open Biomedical Ontologies Foundry下载。非洲爪蟾解剖本体将被用来注释非洲爪蟾基因表达模式和突变体和变形表型。其强大的发展地图将使强大的数据库搜索和数据分析成为可能。我们鼓励社区对本体的更新和改进提出建议。
The frogs Xenopus laevis and Xenopus (Silurana) tropicalis are model systems that have produced a wealth of genetic, genomic, and developmental information. Xenbase is a model organism database that provides centralized access to this information, including gene function data from high-throughput screens and the scientific literature. A controlled, structured vocabulary for Xenopus anatomy and development is essential for organizing these data. We have constructed a Xenopus anatomical ontology that represents the lineage of tissues and the timing of their development. We have classified many anatomical features in a common framework that has been adopted by several model organism database communities. The ontology is available for download at the Open Biomedical Ontologies Foundry . The Xenopus Anatomical Ontology will be used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes. Its robust developmental map will enable powerful database searches and data analyses. We encourage community recommendations for updates and improvements to the ontology.