Regional changes in myocyte structure in model of canine right atrial hypertrophy.
Regional changes in myocyte structure in model of canine right atrial hypertrophy.
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DOI：
10.1152/ajpheart.1994.267.4.h1279
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发表时间：
1994-10
期刊：
影响因子：
--
通讯作者：
P. C. Dolber;R. P. Bauman;J. Rembert;J. Greenfield
中科院分区：
文献类型：
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作者：
P. C. Dolber;R. P. Bauman;J. Rembert;J. Greenfield
为了研究心肌细胞对心房肥厚反应的区域差异，将对照犬与诱导三尖瓣反流引起的右心房肥厚犬进行比较；1年后，右心房体重比比对照组增加了122%。对每只狗的心房间带、附肢和非附肢顶、非附肢侧各一段进行染色，显示心肌细胞轮廓和横小管；测量了肌细胞的横截面积，估计了横小管的患病率。对照犬心房带间肌细胞明显大于其他心房肌细胞，且有更多的横小管。心房肥厚时，右房带间肌细胞大小不明显增加，而其他右房肌细胞大小几乎增加一倍，接近房带间肌细胞大小，但不接近横小管内容物。左心房肌细胞没有增大。因此，心房肌细胞对血流动力学应激的肥厚反应取决于心肌细胞所在的区域，心房肌细胞肥厚不需要横小管增殖。
To investigate regional variation of myocyte response to atrial hypertrophy, control dogs were compared with dogs with right atrial hypertrophy created by induction of tricuspid regurgitation; after 1 yr, right atrial-to-body weight ratio increased 122% over controls. One section from the interatrial band, appendage and nonappendage roofs, and nonappendage side of each atrium of each dog was stained to reveal myocyte outlines and transverse tubules; myocyte cross-sectional areas were measured and transverse tubule prevalence was estimated. In control dogs, interatrial band myocytes were significantly larger and had more transverse tubules than other atrial myocytes. With atrial hypertrophy, right interatrial band myocytes did not increase significantly in size, whereas other right atrial myocytes nearly doubled in size, approaching the size of interatrial band myocytes without approaching the content of transverse tubules. Left atrial myocytes did not increase in size. Thus hypertrophic response of atrial myocytes to hemodynamic stress depends on the region in which the myocytes are found, and atrial hypertrophy does not demand transverse tubule proliferation.