Vision for medicine: Staphylococcus aureus biofilm war and unlocking key's for anti-biofilm drug development
Vision for medicine: Staphylococcus aureus biofilm war and unlocking key's for anti-biofilm drug development
复制标题
医学愿景：金黄色葡萄球菌生物膜战争和解锁抗生物膜药物开发的钥匙
DOI：
10.1016/j.micpath.2018.07.002
复制
发表时间：
2018-10-01
影响因子：
3.8
通讯作者：
Qin, Hua-Li
中科院分区：
文献类型：
--
作者：
Mohammed, Yasser Hussein Eissa;Manukumar, H. M.;Qin, Hua-Li
金黄色葡萄球菌生物膜相关的负担是医学领域根除或避免它的挑战。金黄色葡萄球菌生物膜机制的理解和建立的生物膜形成的可能途径，但仍然需要了解更多，并需要开发新的治疗策略。在这个观点中，我们讨论了突出的生物膜机制，其现有的系统作为活性治疗剂和车辆运输药物的感染部位。药物开发的倒退是由于抗药性沙门氏菌的出现。金黄色。对细菌/生物膜的理解是我们同样总结的一个方面，用于未来可能的药物开发，作为抗耐药S。金黄色葡萄球菌被观察到。
The Staphylococcus aureus biofilm-associated burden is challenging to the field of medicine to eradicate or avoid it. Even though a number of S. aureus biofilm mechanisms understood and established the possible ways of biofilm formation but, still need to know more and require a development of new therapeutic strategies. In this viewpoint, we discuss the underlining biofilm mechanism, its existing systems as active therapeutic agents and as vehicles to transport drugs to the site of infection. The step-back in drug development is due to the emergence of antibiotic-resistant S. aureus. The understanding of bacteria/biofilms is an aspect that we likewise summarize for possible drug development for future as medicine against resistant S. aureus was viewed.