miR-30e-5p represses angiogenesis and metastasis via directly targeting AEG-1 in squamous cell carcinoma of the head and neck
miR-30e-5p represses angiogenesis and metastasis via directly targeting AEG-1 in squamous cell carcinoma of the head and neck
复制标题
miR-30e-5p 通过直接靶向 AEG-1 抑制头颈鳞状细胞癌中的血管生成和转移
作者：
Shuiting Zhang;Guo Li;Chao Liu;Shanhong Lu;Qiancheng Jing;Xiyu Chen;Hua Zheng;Huiling Ma;Diekuo Zhang;Shuling Ren;Zhe Shen;Yunyun Wang;Zhaoyi Lu;Donghai Huang;Pingqing Tan;Jie Chen;Xin Zhang;Yuanzheng Qiu;Yong Liu
转移是决定头颈部鳞状细胞癌（SCCHN）患者治疗策略和预后的关键因素。然而，SCCHN转移的机制知之甚少。我们的研究旨在确定参与SCCHN转移的关键microRNA及其功能机制。在癌症基因组图谱（TCGA）数据分析中，采用定量PCR方法对SCCHN中miR-30 e-5 p的表达水平进行定量分析，并进一步分析其临床意义。采用一系列体外和体内实验来确定miR-30 e-5 p及其靶点AEG-1对SCCHN转移的影响。进一步的机制研究表明AEG-1参与了miR-30 e-5 p介导的血管生成和转移。总之，我们的研究证实miR-30 e-5 p是SCCHN转移中有价值的预测生物标志物和潜在的治疗靶点。
Metastasis is a critical determinant for the treatment strategy and prognosis in patients with squamous cell carcinoma of the head and neck (SCCHN). However, the mechanisms underlying SCCHN metastasis are poorly understood. Our study sought to determine the key microRNA and their functional mechanisms involved in SCCHN metastasis. For The Cancer Genome Atlas (TCGA) data analysis, quantitative PCR was used to quantify the level of miR-30e-5p in SCCHN and its clinical significance was further analyzed. A series of in vitro and in vivo experiments were applied to determine the effects of miR-30e-5p and its target AEG-1 on SCCHN metastasis. A mechanism investigation further revealed that AEG-1 was implicated in the angiogenesis and metastasis mediated by miR-30e-5p. Overall, our study confirms that miR-30e-5p is a valuable predictive biomarker and potential therapeutic target in.SCCHN metastasis.