Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent.
Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent.
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寻常痤疮、红斑痤疮和化脓性汗腺炎的比较转录组分析支持高剂量膳食锌作为治疗剂。
DOI：
10.1101/2023.11.28.23299152
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Wang,Yu
中科院分区：
文献类型：
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作者：
Li,Li;Hajam,Irshad;McGee,JeanS;Tang,Zhengkuan;Zhang,Ye;Badey,Nikil;Mintzer,Esther;Zhang,Zhenrui;Liu,GeorgeY;Church,GeorgeM;Wang,Yu
寻常痤疮、酒渣鼻和化脓性汗腺炎是持久的炎症性皮肤病，经常表现出类似的临床特征，对其独特的诊断提出了相当大的挑战。虽然这些疾病确实表现出一定的相似性，但它们也表现出不同的潜在病理生理机制和治疗方式。深入研究这三种疾病之间的分子相似性和差异性可以为精细诊断，有效管理和有针对性的治疗干预提供宝贵的见解。在这份报告中，我们对这三种疾病的转录组学数据进行了比较分析，阐明了每种疾病特有的差异表达基因和丰富的途径，以及它们之间共享的基因。具体来说，我们确定了多种锌结合蛋白（SERPINA1，S100A7，S100A8，S100A9和KRT16）在所有三种疾病中一致高度上调的基因。我们的假设表明，这些蛋白质可以结合和螯合锌，可能导致局部缺锌和炎症加剧。我们确定高剂量饮食锌是一种有前途的治疗方法，并通过在痤疮小鼠模型中的验证证实了其有效性。
Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these conditions do exhibit certain resemblances, they also demonstrate distinct underlying pathophysiological mechanisms and treatment modalities. Delving into both the molecular parallels and disparities among these three disorders can yield invaluable insights for refined diagnostics, effective management, and targeted therapeutic interventions. In this report, we present a comparative analysis of transcriptomic data across these three diseases, elucidating differentially expressed genes and enriched pathways specific to each ailment, as well as those shared among them. Specifically, we identified multiple zinc‐binding proteins (SERPINA1, S100A7, S100A8, S100A9 and KRT16) as consistently highly upregulated genes across all three diseases. Our hypothesis suggests that these proteins could bind and sequester zinc, potentially leading to localized zinc deficiency and heightened inflammation. We identified high‐dose dietary zinc as a promising therapeutic approach and confirmed its effectiveness through validation in an acne mouse model.