Increased serum concentration of soluble CD14 is a prognostic marker in gram-positive sepsis
Increased serum concentration of soluble CD14 is a prognostic marker in gram-positive sepsis
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DOI：
10.1006/clin.1996.0128
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发表时间：
1996-09-01
期刊：
影响因子：
--
通讯作者：
Graninger, W
中科院分区：
文献类型：
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作者：
Burgmann, H;Winkler, S;Graninger, W
血清sCD14浓度升高与革兰氏阴性败血症和创伤患者预后不良相关。在本研究中，测量了革兰氏阳性脓毒症患者的血清sCD14浓度，并与革兰氏阴性脓毒症和非脓毒症重症监护病房患者进行了比较。此外，血清sCD14浓度与患者预后相关。28名革兰氏阳性（8名非幸存者/20名幸存者）和10名革兰氏阴性菌血症患者（3名非幸存者/7名幸存者）在符合Bone等人定义的脓毒症标准的当天（第0天）、第4天和第7天获得血清样本，并与10名非脓毒症ICU患者和10名健康志愿者进行比较。ELISA法检测血清sCD14浓度。革兰氏阳性非幸存者血清sCD14浓度在第4天和第7天显著高于革兰氏阳性幸存者（第4天：5.85 +/- 0.48 vs 4.07 +/- 0.43 μ g/ml, P < 0.05；第7天：6.12 +/- 0.46 vs 3.53 +/- 0.33 μ g/ml, P < 0.01）。此外，在任何观察时间，革兰氏阳性非幸存者的sCD14浓度均显著高于非脓毒症ICU患者和健康志愿者。然而，革兰氏阳性和革兰氏阴性患者之间没有显著差异。综上所述，血清sCD14水平可以被证明是革兰氏阳性脓毒症过程中一个很好的预后指标。浓度升高与高死亡率有关。(C) 1996学术出版社，Inc.
Increased serum sCD14 concentrations are associated with poor outcome in Gram-negative sepsis and trauma patients. In the present study serum sCD14 concentrations were measured in patients with Grampositive sepsis and compared with Gram-negative septic and nonseptic intensive care unit patients. Furthermore, serum sCD14 concentration was correlated with patient's outcome. Serum samples of 28 Grampositive (8 nonsurvivors/20 survivors) and 10 Gramnegative bacteriemic patients (3 nonsurvivors/7 survivors) were obtained at the day they met the sepsis criteria defined by Bone et al. (Day 0) and at Days 4 and 7 and compared with 10 nonseptic ICU patients and 10 healthy volunteers. Serum concentrations of sCD14 were measured by ELISA. Significantly higher sCD14 serum concentrations were found on Days 4 and 7 in Gram-positive nonsurvivors than in Gram-positive survivors (Day 4: 5.85 +/- 0.48 vs 4.07 +/- 0.43 mu g/ml, P < 0.05; Day 7: 6.12 +/- 0.46 vs 3.53 +/- 0.33 mu g/ml, P < 0.01). In addition, sCD14 concentrations of Gram-positive nonsurvivors were significantly higher than those of nonseptic ICU patients and healthy volunteers at any time of observation. However, no significant difference was calculated between Gram-positive and Gram-negative patients. Summarizing our results, the serum level of sCD14 could be proven to be a good prognostic marker in the course of Gram-positive sepsis. Increased levels are associated with a high mortality. (C) 1996 Academic Press, Inc.