Smoking and dementia in male British doctors: prospective study
Smoking and dementia in male British doctors: prospective study
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DOI：
10.1136/bmj.320.7242.1097
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发表时间：
2000-04-22
影响因子：
--
通讯作者：
Sutherland, I
中科院分区：
文献类型：
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作者：
Doll, R;Peto, R;Sutherland, I
目的探讨吸烟与痴呆之间的关系。设计前瞻性研究。研究对象为1951年以来随访的英国男性医生。研究对象为34439名男性医生，其中死亡24133人。结果所有类型痴呆合并的相对危险度为0.96（95%置信区间0.78至1.18），基于473例死亡，平均年龄81岁。对于可能或确定的阿尔茨海默病，持续吸烟者的相对风险为0.99（0.78至1.25），基于370例平均年龄为82岁的死亡。然而，总的来说，其他前瞻性研究表明，一个直接的，虽然没有明确的显着，吸烟和一般的痴呆症和阿尔茨海默氏症的发病之间的关联，特别是。结论与以前的建议相反，持续吸烟并没有实质上降低特定年龄的阿尔茨海默氏症或痴呆症的发病率一般。如果有的话，它可能会增加而不是减少比率，但对严重痴呆症的任何净影响在任何一个方向上都不会很大。
Objective To assess the possible association between smoking and dementia.Design Prospective studySetting Cohort of British male doctors followed up since 1951.Subjects 34 439 male British doctors, with 24 133 deaths recorded.Results For all types of dementia combined the relative risk was 0.96 (95% confidence interval 0.78 to 1.18), based on 473 deaths at a mean age of 81 years. For probable or definite Alzheimer's disease, the relative risk in continuing smokers was 0.99 (0.78 to 1.25), based on 370 deaths at a mean age of 82 years. In aggregate, however, the other prospective studies indicate a direct, although not clearly significant, association between smoking and the onset of dementia in general and of Alzheimer's disease in particular.Conclusions Contrary to previous suggestions persistent smoking does not substantially reduce the age specific onset rate of Alzheimer's disease or of dementia in general. If anything, it might increase rather than decrease the rate, but any net effect on severe dementia cannot be large in either direction.