Enhanced methamphetamine-induced conditioned place preference in risk-taking rats
Enhanced methamphetamine-induced conditioned place preference in risk-taking rats
复制标题
甲基苯丙胺诱导的冒险大鼠条件性位置偏好增强
DOI：
10.1016/j.bbr.2019.112299
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发表时间：
2020
影响因子：
2.7
通讯作者：
Yamada Kazuo
中科院分区：
文献类型：
--
作者：
Takahashi Katsumasa;Toyoshima Michimasa;Ichitani Yukio;Yamada Kazuo
患有精神疾病的患者，如赌博和物质使用，往往表现出适应不良的决策。在这项研究中，我们评估了个体差异的冒险行为，使用大鼠赌博任务（GT）和研究之间的关系，冒险行为和药物依赖的脆弱性，使用甲基苯丙胺（METH）诱导的条件性位置偏爱（CPP）。在GT中，使用放射状臂迷宫，训练雄性Long-Evans大鼠选择三个选择臂（低风险/低回报（L-L），高风险/高回报（H-H）和空臂）中的一个，每天16次试验，持续14天。METH诱导的CPP包括6个阶段：习惯化、条件反射、偏好测试（测试I）、消退、消退测试（测试II）和恢复测试（测试III）。结果表明，选择H-H臂的百分比与偏好测试中在MET配对隔室中花费的时间百分比呈显著正相关，但与消退和恢复测试无关，表明冒险大鼠更容易产生药物依赖。
Patients with psychiatric disorders, such as gambling and substance use, tend to exhibit maladaptive decision-making. In this study, we assessed individual differences in risk-taking behaviors using a rat gambling task (GT) and investigated the relationship between risk-taking behaviors and vulnerability to drug dependence using methamphetamine (METH)-induced conditioned place preference (CPP). In the GT using a radial arm maze, male Long-Evans rats were trained to choose one of three choice arms (a low-risk/low reward (L-L), a high-risk/high reward (H-H), and an empty arm) in 16 trials per day for 14 days. METH-induced CPP consisted of 6 sessions: habituation, conditioning, preference test (Test I), extinction, extinction test (Test II), and reinstatement test (Test III). Results demonstrated that the percentage of choosing the H-H arm was significantly positively correlated with the percentage of time spent in the METH-paired compartment in the preference test, but not with the extinction and reinstatement tests, suggesting that risk-taking rats are more vulnerable to drug dependence.