The development of the blood supply to the heart in the embryo pig
The development of the blood supply to the heart in the embryo pig
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DOI：
10.1002/aja.1000600103
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发表时间：
1936-11-01
影响因子：
--
通讯作者：
Bennett, HS
中科院分区：
文献类型：
--
作者：
Bennett, HS
未注射和注射的猪胚胎心脏的切片显示，血窦、冠状动脉和静脉的首次出现与兔的仅略有不同。冠状血管将心室包埋在心外膜下神经丛中，该神经丛供应大部分心室30 mm，在正弦曲线之间发送细枝。在20 mm猪心中，窦状隙形成通向心室的主要循环通道，在45 mm阶段维持左右心室之间的连接，并在135 mm阶段与冠状血管共存。回归开始于窦状隙的心外膜端，并向中央向主腔发展。生长中的骨小梁迫使窦的两个壁粘连在一起，将内皮细胞减少为无腔股，随后消失。较小的终端凹陷没有留下痕迹。较大的窦状隙在其尾部留下一条无血管的内膜下结缔组织。左心室壁冠状血管侵入心脏和血窦退化的时间早于右心室壁。冠状动脉血管和窦状动脉在它们共存的整个时期内紧密地相互交错，但除了罕见的动脉瘤外，它们仍然相互分离，这些动脉瘤是所谓的“底比斯血管”的前身。“成人的心脏循环模式是由150毫米建立的。
Sections of uninjected and injected pig embryo hearts show that the first appearance of sinusoids, coronary arteries, and veins differs only slightly from that of the rabbit. The coronary vessels invest the ventricles in a subepicardial plexus which supplies most of the ventricles by 30 mm., sending twigs between sinusoids. Sinusoids form the main circulatory channels to the ventricles in 20-mm. pig hearts, maintain connection between right and left ventricle through the 45-mm. stage, and coexist with coronary vessels through the 135-mm. stage. Regression starts at the epicardial end of the sinusoidal recesses and progresses centrally toward the main lumen. Growing trabeculae force together the 2 walls of the sinusoid which adhere, reducing the endo-thelium to a lumenless strand which later disappears. Smaller terminal recesses leave no vestige. Larger sinusoids leave in their wake a solid strand of avascular subendocardial connective tissue. Invasion of the heart by coronary vessels and regression of the sinusoids take place earlier in the wall of the left ventricle than in that of the right. The coronary vessels and sinusoids interdigitate intimately during their entire period of coexistence, but remain mutually separate except for infrequent anastomoses which are precursors of the so-called "Thebesian vessels." The adult pattern of cardiac circulation is established by 150 mm.