Morphologic Change of In Vivo Porcine Liver Under 13 mm Hg Pneumoperitoneum Pressure
Morphologic Change of In Vivo Porcine Liver Under 13 mm Hg Pneumoperitoneum Pressure
复制标题
13 mm Hg气腹压下体内猪肝脏的形态变化
DOI：
10.1097/sle.0000000000000973
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发表时间：
2021-12-01
影响因子：
1
通讯作者：
Jia, Fucang
中科院分区：
文献类型：
--
作者：
Zhang, Wenyu;Yin, Dalong;Jia, Fucang
背景：临床上，在大范围肝切除前，必须准确计算总肝体积和残肝体积。然而，术中气腹可能会影响肝脏体积。肝脏体积变化的变化也会影响模拟和增强现实导航系统的准确性，这些系统通常首先在动物模型中得到验证。本研究观察了活体猪肝脏在13 mm Hg气腹压力下的形态变化。材料和方法：20头雄性猪在无气腹、气腹压力为13 mm Hg的条件下进行增强CT扫描。结果：测量了肝脏的表面积和体积以及主动脉腔、下腔静脉腔和门静脉腔的血管直径。13 mm Hg气腹前后肝表面积和体积(P=0.000)、门静脉横径(P=0.038)、下腔静脉纵径(P=0.033)、门静脉纵径(P=0.036)、下腔静脉血管横截面积(P=0.028)、门静脉(P=0.038)差异有统计学意义。结论：本研究表明，猪在13 mm Hg压力下形成气腹会引起肝脏的形态改变，影响面积和体积以及血管的直径。
Background: Clinically, the total and residual liver volume must be accurately calculated before major hepatectomy. However, liver volume might be influenced by pneumoperitoneum during surgery. Changes in liver volume change also affect the accuracy of simulation and augmented reality navigation systems, which are commonly first validated in animal models. In this study, the morphologic changes in porcine livers in vivo under 13 mm Hg pneumoperitoneum pressure were investigated. Materials and Methods: Twenty male pigs were scanned with contrast-enhanced computed tomography without pneumoperitoneum and with 13 mm Hg pneumoperitoneum pressure. Results: The surface area and volume of the liver and the vascular diameter of the aortic lumen, inferior vena cava lumen, and portal vein lumen were measured. There were statistically significant differences in the surface area and volume of the liver (P=0.000), transverse diameter of the portal vein (P=0.038), longitudinal diameter of the inferior vena cava (P=0.033), longitudinal diameter of the portal vein (P=0.036), vascular cross-sectional area of the inferior vena cava (P=0.028), and portal vein (P=0.038) before and after 13 mm Hg pneumoperitoneum pressure. Conclusions: This study indicated that the creation of pneumoperitoneum at 13 mm Hg pressure in a porcine causes liver morphologic alterations affecting the area and volume, as well as the diameter of a blood vessel.