Development of a simultaneous PET/MRI scanner
Development of a simultaneous PET/MRI scanner
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同步 PET/MRI 扫描仪的开发
DOI：
10.1109/nssmic.2004.1466621
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
S. Stoll
中科院分区：
文献类型：
--
作者：
D. Schlyer;W. Rooney;C. Woody;P. Vaska;A. Kriplani;S. Stoll
磁共振成像（MRI）和正电子发射断层扫描（PET）相结合的扫描仪将为核医学带来巨大的好处。通过MRI和磁共振波谱（MRS）提供的波谱给出的解剖细节补充了PET获得的定量生理成像。由于光电倍增管（PMT）及其相关电子器件与MRI的高磁场的不兼容性，以及由于MR扫描仪的有限患者端口而对PET相机尺寸的显著限制，这样的设备尚未成为现实。固态电子学的最新进展已经开启了用雪崩光电二极管（APD）取代光电倍增管的可能性，雪崩光电二极管（APD）是紧凑的并且不具有PMT对磁场的脆弱性。目前，我们正计划建立一个微型PET断层扫描仪，只使用固态电子给一个组合的MRI/PET扫描仪的小动物。这项技术一旦开发出来，就可以扩展到人体扫描仪设计中。
A combined magnetic resonance imaging (MRI) and positron emission tomography (PET) scanner would be a great benefit to nuclear medicine. The anatomical detail given by MRI and spectroscopy available with magnetic resonance spectroscopy (MRS) complement the quantitative physiological imaging obtained with PET. Such a device has not become a reality because of the incompatibilities of photomultiplier tubes (PMTs) and their associated electronics with MRI's high magnetic fields, as well as significant constraints on PET camera size due to the limited patient port of MR scanners. Recent advances in solid-state electronics have opened the possibility of replacing photomultiplier tubes with avalanche photodiodes (APDs) that are compact and do not share the vulnerabilities of PMTs to magnetic fields. Currently, we are planning to build a miniature PET tomograph using only solid-state electronics to give a combination MRI/PET scanner for small animals. This technology, once developed, can be extended to human scanner designs.