Hydration-Enhanced Lubricating Electrospun Nanofibrous Membranes Prevent Tissue Adhesion
Hydration-Enhanced Lubricating Electrospun Nanofibrous Membranes Prevent Tissue Adhesion
复制标题
水合增强润滑静电纺纳米纤维膜可防止组织粘附
DOI：
10.34133/2020/4907185
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发表时间：
2020-03-19
期刊：
影响因子：
11
通讯作者：
Cui, Wenguo
中科院分区：
文献类型：
--
作者：
Cheng, Liang;Wang, Yi;Cui, Wenguo
润滑是人体组织有效发挥功能的关键，对舒适度有重大影响。然而，润滑纳米纤维膜的构建尚未见报道，特别是使用一步表面改性方法。在这里，受关节软骨超润滑机制的生物启发，我们通过将多巴胺甲基丙烯酰胺（DMA）和2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）合成的共聚物一步原位接枝到电纺聚己内酯（PCL）上，成功构建了水合增强润滑纳米纤维。 纳米纤维。两性离子MPC结构为纳米纤维表面提供了水合润滑行为。润滑纳米纤维膜的摩擦系数（COF）显着降低，比纯PCL纳米纤维低约65%，无论水合情况，纯PCL纳米纤维在摩擦下都很容易磨损。然而，润滑纳米纤维表现出良好的耐磨性能。此外，与纯PCL纳米纤维相比，它们具有很强的成纤维细胞抗粘附能力。第7天，细胞密度减少约9倍，细胞面积减少约12倍。此外，体内抗腱粘附数据显示，润滑纳米纤维组的粘附评分明显较低，抗组织粘附更好。总而言之，我们开发的水合增强润滑纳米纤维在生物医学领域（例如防粘膜）显示出有前景的应用。
Lubrication is the key to efficient function of human tissues and has significant impact on the comfort level. However, the construction of a lubricating nanofibrous membrane has not been reported as yet, especially using a one-step surface modification method. Here, bioinspired by the superlubrication mechanism of articular cartilage, we successfully construct hydration-enhanced lubricating nanofibers via one-step in situ grafting of a copolymer synthesized by dopamine methacrylamide (DMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) onto electrospun polycaprolactone (PCL) nanofibers. The zwitterionic MPC structure provides the nanofiber surface with hydration lubrication behavior. The coefficient of friction (COF) of the lubricating nanofibrous membrane decreases significantly and is approximately 65% less than that of pure PCL nanofibers, which are easily worn out under friction regardless of hydration. The lubricating nanofibers, however, show favorable wear-resistance performance. Besides, they possess a strong antiadhesion ability of fibroblasts compared with pure PCL nanofibers. The cell density decreases approximately 9-fold, and the cell area decreases approximately 12 times on day 7. Furthermore, the in vivo antitendon adhesion data reveals that the lubricating nanofiber group has a significantly lower adhesion score and a better antitissue adhesion. Altogether, our developed hydration-enhanced lubricating nanofibers show promising applications in the biomedical field such as antiadhesive membranes.