Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer
Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer
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DOI：
10.1038/sj.bjc.6601621
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发表时间：
2004-02-23
影响因子：
8.8
通讯作者：
Uchitomi, Y
中科院分区：
文献类型：
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作者：
Suzuki, S;Akechi, T;Uchitomi, Y
本研究的目的是研究日本癌症患者每天摄入omega-3脂肪酸与抑郁之间的关系。采用食物频率问卷对771例新诊断的原发性肺癌患者的omega-3脂肪酸摄入量进行评估，并使用医院焦虑和抑郁量表中抑郁分量表的临界值来检验抑郁的患病率。在调整潜在混杂因素后，二十碳五烯酸(C20：5N-3)和二十二碳五烯酸(C22：6N-3)摄入量最高四分位数的患者与最低四分位数的患者相比，抑郁的优势比(OR)无显著差异。另一方面，α-亚麻酸(C18：3n-3)摄入量最高四分位数(调整后OR=0.5，95%CI：0.31~0.71，趋势=0.004)和总omega-3脂肪酸摄入量最高四分位(调整OR=0.55，95%CI：0.35~0.88，P趋势=0.022)之间的OR值有显著差异。这些结果表明，在日本新诊断的肺癌患者中，总二十碳五烯酸和二十二碳五烯酸的摄入量可能与抑郁无关。但a-亚麻酸摄入量和总omega-3脂肪酸摄入量可能是。
The aim of the present study was to examine the association between daily omega-3 fatty acid intake and depression in Japanese cancer patients. Omega-3 fatty acid intake in 77 1 patients with newly diagnosed primary lung cancer was evaluated using a food-frequency questionnaire, and the prevalence of depression was examined using the cutoff values for the depression subscale included in the Hospital Anxiety and Depression Scale. After adjustment for potential confounding factors, the odds ratio (OR) for depression among patients in the highest quartile of the total eicosapentaenoic acid- (C20:5n-3) and docosapentaenoic acid (C22:6n-3)-intake group compared with patients in the lowest quartile was not significantly different. On the other hand, the OR among the highest quartile of alpha-linolenic acid (C18:3n-3) intake (adjusted OR = 0.50, 95% CI: 0.31-0.71, P for trend = 0.004) and the highest quartile of total omega-3 fatty acid intake (adjusted OR = 0.55, 95% CI: 0.35-0.88, P for trend = 0.022) were significantly different, These results suggest that total eicosapentaenoic acid and docosapentaenoic acid intake might not be associated with depression in Japanese patients with newly diagnosed lung cancer, but that a-linolenic acid intake and total omega-3 fatty acid intake might be.