Cranial-cervical dyskinesias: an overview.
Cranial-cervical dyskinesias: an overview.
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颅颈运动障碍：概述。
DOI：
10.1093/oxfordjournals.brain.a101863
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发表时间：
1988
影响因子：
--
通讯作者：
J. Jankovic
中科院分区：
文献类型：
--
作者：
J. Jankovic
特发性眼睑痉挛和颅肌张力障碍是病因不明的局灶性肌张力障碍。帕金森病患者急性多巴胺缺乏引起的眼睑痉挛可能通过黑质网状部(SNPR)限制了眼跳的启动。如果特发性眼睑痉挛和颅肌张力障碍类似地限制眼跳，那么可能涉及选择性的、体位排列的通路，如SNPR。为了测试这种可能性，我们测量了特发性眼睑痉挛和颅肌张力障碍患者的记忆力和视觉引导眼跳。这两种眼跳的潜伏期要么显著延长，要么变化太大，而这些快速眼动的准确性和峰值速度与年龄匹配的对照组相似。特发性眼睑痉挛和颅肌张力障碍改变了眼球跳动的启动。眼睑痉挛可能涉及眼睑、眼跳和头颈运动控制的皮质下区域或通路，如SNPR。
Essential blepharospasm and cranial dystonia are related focal dystonias of unknown aetiology. Blepharospasm induced by acute dopamine depletion in parkinsonism restricts saccade initiation possibly via the substantia nigra pars reticulata (SNpr). If essential blepharospasm and cranial dystonia similarly restrict saccades, then a selective, somatotopically arranged pathway such as the SNpr may be involved. To test this possibility memory-contingent and visually-guided saccades were measured in patients with essential blepharospasm and cranial dystonia. The latency of both forms of saccades was either significantly prolonged or excessively variable, while the accuracy and peak velocity of these fast eye movements were similar to age-matched control subjects. Essential blepharospasm and cranial dystonia alter the initiation of saccadic eye movements. Subcortical brain regions or pathways where eyelid, saccade and cranial/cervical motor control are somatotopically approximated, such as the SNpr, may be involved in blepharospasm.