Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus.
Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus.
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DOI：
10.1016/j.neurobiolaging.2013.03.034
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发表时间：
2013-10
影响因子：
4.2
通讯作者：
Wenk GL
中科院分区：
文献类型：
--
作者：
Bardou I;Brothers HM;Kaercher RM;Hopp SC;Wenk GL
目前的研究调查了这样一个假设，即促炎环境的持续时间在大脑的反应中起着关键作用，导致认知，生物化学和病理学的负面后果。将脂多糖（LPS）或aCSF缓慢（250 μ g/hr）输注到年轻（3月龄）、成年（9月龄）或老年（23月龄）雄性F-344大鼠的第IV脑室中，持续21或56天。然后在水池任务中测试大鼠，并测定促炎和抗炎蛋白和基因的内源性海马水平以及海马能功能的指标。与大鼠年龄相比，LPS输注的持续时间对1）空间工作记忆，2）海马内活化小胶质细胞的密度和分布，以及3）海马内细胞因子蛋白和基因表达谱的影响最大。神经炎症的持续时间和年龄依赖性后果可以解释为什么成年人对抗炎治疗反应积极，而老年人则没有。
The current study investigated the hypothesis that the duration of the pro-inflammatory environment plays a critical role in the brain’s response that result in negative consequences upon cognition, biochemistry and pathology. Lipopolysaccharide (LPS) or aCSF was slowly (250 ηg/hr) infused into the IVth ventricle of young (3 mo), adult (9 mo) or aged (23 mo) male F-344 rats for 21 or 56 days. The rats were then tested in the water pool task and endogenous hippocampal levels of pro- and anti-inflammatory proteins and genes as well as indicators of glutamatergic function were determined. The duration of the LPS infusion, as compared to the age of the rat, had the greatest impact upon 1) spatial working memory, 2) the density and distribution of activated microglia within the hippocampus, and 3) the cytokine protein and gene expression profiles within the hippocampus. The duration- and age-dependent consequences of neuroinflammation may explain why adult humans respond positively to anti-inflammatory therapies while aged humans do not.
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DOI：
10.1523/jneurosci.1729-12.2012
发表时间：
2012-10-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cameron B;Tse W;Lamb R;Li X;Lamb BT;Landreth GE
通讯作者：
Landreth GE
影响因子：
2.3
作者：
Drye LT;Zandi PP
通讯作者：
Zandi PP
影响因子：
9.3
作者：
Cribbs DH;Berchtold NC;Perreau V;Coleman PD;Rogers J;Tenner AJ;Cotman CW
通讯作者：
Cotman CW
影响因子：
9.9
作者：
Aarsland, D;Andersen, K;Kragh-Sorensen, P
通讯作者：
Kragh-Sorensen, P
DOI：
10.1016/j.jalz.2010.12.014
发表时间：
2011-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Breitner JC;Baker LD;Montine TJ;Meinert CL;Lyketsos CG;Ashe KH;Brandt J;Craft S;Evans DE;Green RC;Ismail MS;Martin BK;Mullan MJ;Sabbagh M;Tariot PN;ADAPT Research Group
通讯作者：
ADAPT Research Group