The diffusion MRI signature index is highly correlated with immunohistochemical status and molecular subtype of invasive breast carcinoma
The diffusion MRI signature index is highly correlated with immunohistochemical status and molecular subtype of invasive breast carcinoma
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DOI：
10.1007/s00330-022-08562-4
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发表时间：
2022-04-08
影响因子：
5.9
通讯作者：
Yamada, Kei
中科院分区：
文献类型：
--
作者：
Goto, Mariko;Le Bihan, Denis;Yamada, Kei
目的 评估特征指数 (S-index)（一种先进的扩散 MRI 标记）与浸润性乳腺癌的免疫组织化学 (IHC) 状态、增殖率和分子亚型的关系。方法对2017年至2021年浸润性癌患者进行回顾性研究。所有患者均接受3-T系统动态增强MRI和DWI检查。对于 DWI，使用三个 b 值（0、200 和 1500 s/mm(2)）来得出 S 指数。在 DWI 上手动将三维 ROI 放置在整个肿瘤上。将平均值和第 85 个百分位 S 指数值与 IHC 状态、增殖率和病变分子亚型进行比较。结果 该研究包括 153 名患有 160 例浸润性癌的患者（平均年龄 60 +/- 13 岁）。雌激素受体阳性（平均值，p = .005；第 85 个百分位，p < .001）和孕激素受体阳性（平均值，p = .003；第 85 个百分位，p < .001）肿瘤中的 S 指数显着较高，而人表皮生长因子受体 2 (HER2) 阳性肿瘤（平均值，p = .023；第 85 个百分位，p < .001）中的 S 指数值显着较低。第 85 个百分位数，p < .001）。乳腺癌亚型之间的平均值和第 85 个百分位 S 指数值存在显着差异（平均值，p = .015；第 85 个百分位，p = .002），这些值预测 IHC 状态的 AUC 对于 HER2 分别为 0.64 和 0.66，对于激素受体分别为 0.70 和 0.74。结论 DWI S 指数在免疫组织化学状态与良好预后相关的浸润性癌中显示出显着较高的值，表明其可作为非侵入性成像生物标志物来估计 IHC 状态和指导治疗。
Objectives To evaluate the relationship of the signature index (S-index), an advanced diffusion MRI marker, and the immunohistochemical (IHC) status, proliferation rate, and molecular subtype of invasive breast cancers. Methods A retrospective study of patients with invasive carcinoma was conducted between 2017 and 2021. All patients underwent dynamic contrast-enhanced MRI and DWI using a 3-T system. For DWI, three b values (0, 200, and 1500 s/mm(2)) were used to derive the S-index. Three-dimensional ROIs were manually placed over the whole tumor on DWI. Mean and 85(th) percentile S-index values were compared to the IHC status, proliferation rate, and molecular subtypes of lesions. Results The study included 153 patients (mean age, 60 +/- 13 years) with 160 invasive carcinomas. S-index values were significantly higher in estrogen receptor-positive (mean, p = .005; 85(th) percentile, p < .001) and progesterone receptor-positive (mean, p = .003; 85(th) percentile, p < .001) tumors, and significantly lower in human epidermal growth factor receptor 2 (HER2) - positive tumors (mean, p = .023; 85(th) percentile, p < .001). Mean and 85(th) percentile S-index values were significantly different among breast cancer subtypes (mean, p = .015; 85(th) percentile, p = .002), and the AUC of these values for the prediction of IHC status were 0.64 and 0.66 for HER2, and 0.70 and 0.74 for hormone receptors, respectively. Conclusions The DWI S-index showed significantly higher values in invasive carcinomas with immunohistochemical status associated with good prognosis, suggesting its usefulness as a noninvasive imaging biomarker to estimate IHC status and orient treatment.