Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and γ-ray-induced tumors
Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and γ-ray-induced tumors
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DOI：
10.1126/sciadv.aax5940
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发表时间：
2020-04-01
期刊：
影响因子：
13.6
通讯作者：
Weil, M. M.
中科院分区：
文献类型：
--
作者：
Edmondson, E. F.;Gatti, D. M.;Weil, M. M.
来自银河系宇宙辐射暴露的癌症风险被认为是载人火星使命的潜在“亮点”。由于我们对高电荷、高能（HZE）离子的致癌效应的了解有限，计算航天机组人员面临的实际风险变得复杂，这种辐射类型没有人类暴露数据。使用遗传多样性的小鼠模型，我们发现HZE离子诱导的肿瘤的组织型谱与自发性和γ射线诱导的肿瘤的谱相似，并且对于某些肿瘤类型，控制亲合性的基因组位点在组之间重叠。在发生这种重叠的地方，这种重叠表明无论辐射照射类型如何，都存在共同的肿瘤发生机制，并支持使用来自γ射线照射的人类流行病学数据来预测银河宇宙射线的癌症风险。
Cancer risk from galactic cosmic radiation exposure is considered a potential "showstopper" for a manned mission to Mars. Calculating the actual risks confronted by spaceflight crews is complicated by our limited understanding of the carcinogenic effects of high-charge, high-energy (HZE) ions, a radiation type for which no human exposure data exist. Using a mouse model of genetic diversity, we find that the histotype spectrum of HZE ion-induced tumors is similar to the spectra of spontaneous and y-ray-induced tumors and that the genomic loci controlling susceptibilities overlap between groups for some tumor types. Where it occurs, this overlap indicates shared tumorigenesis mechanisms regardless of the type of radiation exposure and supports the use of human epidemiological data from y-ray exposures to predict cancer risks from galactic cosmic rays.