Evolving endosomes: how many varieties and why?
Evolving endosomes: how many varieties and why?
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DOI：
10.1016/j.ceb.2005.06.008
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发表时间：
2005-08-01
影响因子：
7.5
通讯作者：
Rodriguez-Boulan, E
中科院分区：
文献类型：
--
作者：
Perret, E;Lakkaraju, A;Rodriguez-Boulan, E
在过去的几年里，细胞生物学家对内体多样性的洞察力在形式和功能方面都有了显着的提高。这种理解已经被强大的新技术的可用性所促进，这些新技术允许在真实的时间内对内吞过程中的货物和机器进行成像，并且我们能够通过RNA干扰来抑制这种机器的组件。从这些研究中出现的图像是一个高度复杂的，动态的和适应性的内体系统，在不同的点与细胞的分泌系统相互作用。
The cell biologist's insight into endosomal diversity, in terms of both form and function, has increased dramatically in the past few years. This understanding has been promoted by the availability of powerful new techniques that allow imaging of both cargo and machinery in the endocytic process in real time, and by our ability to inhibit components of this machinery by RNA interference. The emerging picture from these studies is of a highly complex, dynamic and adaptable endosomal system that interacts at various points with the secretory system of the cell.